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A Computational Model of Cytosolic and Mitochondrial [Ca2＋] in Paced Rat Ventricular Myocytes
JaeBoumYoum, SeongWooChoi, ChangHanJang, HyoungKyuKim, ChaeHunLeem, NariKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 23 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 5 217-239 (23 pages)
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2＋ transients and compared the results with those from computer simulation. In rat ventricular myocytes, increasing the rate of stimulation (1∼3 Hz) made both the diastolic and systolic [Ca2＋] bigger in mitochondria as well as in cytosol. As L-type Ca2＋ channel has key influence on the amplitude of Ca2＋-induced Ca2＋ release, the relation between stimulus frequency and the... -
Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring
JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the... -
Mechanisms of Selective Antimicrobial Activity of Gaegurin 4
HeejeongKim, ByeongJaeLee, MunHanLee, SeongGeunHong, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 7 39-48 (10 pages)
even at higher concentration (100Ռg/ml). GGN4 induced larger conductances in the planar bilayers which were formed with lipids extracted from Gram-positive B. subtilis than in those from E. coli (p＜0.01), however, the effects of GGN4 were not selective in the bilayers formed with lipids from E. coli and red blood cells. Addition of an acidic phospholipid, phosphatidylserine to planar bilayers increased the GGN4-induced membrane conductance (p＜0.05), but addition of phosphatidylcholine or... -
Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death
MoonHyunBu, KyeongAhLee, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 1 315-322 (8 pages)
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were induced death by expressing FADD in the absence of tetracycline (FADD-SMC) triggered death of normal SMC. DNA fragmentation and caspase-3 activation were observed in dying SMC by conditioned media. FADD-SMC showed transcriptional activation of tumor necrosis factor (TNF)-α. Conditioned medium... -
Lipopolysaccharide Inhibits Proliferation of the Cultured Vascular Smooth Muscle Cells by Stimulating Inducible Nitric Oxide Synthase and Subsequent Activation of Guanylate Cyclase
HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 7 343-351 (9 pages)
in LDH activity. L-arginine, an NO substrate, alone tended to reduce cell count without affecting nitrite concentration or LDH level. Aminoguanidine, an iNOS specific inhibitor, inhibited LPS-induced reduction of cell numbers and reduced the nitrite concentration in the culture medium. LY 83583, a guanylate cyclase inhibitor, suppressed the inhibitory actions of LPS and SNP on VSMC proliferation. LPS increased amounts of iNOS protein and iNOS mRNA in a concentration-dependent manner. These resul... -
한국인 알코올 의존 환자의 제2알데히드탈수소효소 유전자형 빈도
백인호, 이철, 이수정, 이창욱, 김정진, 전태연, 한상익, 함웅 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 1호 13 149-158 (10 pages)
연구목적：본 연구는 알코올의 대사과정에서 중요한 제2알데히드 탈수소효소(aldehyde dehydrogenase (ALDH)2)의 유전자형이 알코올 의존의 발병이나 임상 변인과 어떠한 연관성을 갖는지 알아보기 위하여 시 행되었다. 방 법：141명의 알코올의존증환자와 144명의 대조군에서 ALDH2 유전자형을 제한효소법에 의하여 형벌 하고 비교하였으며 환자군에서 ALDH2 유전자형 빈도에 따른 임상 양상의 차이를 조사하였다. 결 과： 1) 알코올 의존증 환자군은 대조군보다 유의하게 ALDH2*1/1의 빈도가 높고 변이형 ALDH2인 ALDH2*1/2 와... -
정신분열병 치료효과에 대한 신경인지기능의 예측력에 관한 연구
오병훈, 이희상, 최의헌, 현명호, 조현상, 유계준 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 6 1065-1073 (9 pages)
연구목적： 신경인지기능검사가 정신분열병 환자의 예후 및 치료에 대한 반응을 예측할 수 있는 인자로 작용할 수 있 다는 연구결과들이 있었다. 이들 연구에서는 인지기능을 측정하는 검사도구 중 일부를 이용하여 치료결과를 예측해 본 것이므로 저자들은 보다 광범위한 신경인지기능검사를 이용하여 이들 중 어떤 검사결과가 정신분 열병 환자들에 대한 치료결과를 얼마나 예측해 줄 수 있는지를 알아보기 위해 본 연구를 수행하였다. 방 법： 연구대상은 DSM-Ⅳ 진단기준에 의거 정신분열병으로 진단된 입원 환자 33명을 대상으로... -
24시간 혈중농도와 신배설률을 이용한 리툼 치료량 예측법의 평가비교
김진세, 정인과, 곽동일 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1992, 제 31권 제 4호 7 708-715 (8 pages)
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Isolation and Characterization of Endosome Subpopulation in Chinese Hamster Ovarian Cells
Suh, Duk-Joon, Park, Mi-Yeon, Jung, Dong-Keun, Bae, Hae-Rahn 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 2 197-208 (12 pages)
Endosomes lower their internal pH by an ATP-driven proton pump, which is critical to dissociation of many receptor-ligand complexes, the first step in the intracellular sorting of internalized receptors and ligands. Endosomes are known to exhibit n great range of pH values that can vary between 5.0 and 7.0 within a single cell although the factors that regulate endosomal pH remain uncertain. To evaluate the morphological and topological differences of endosomes in the different stages, confocal...
