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121.

Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression

YoungSunKim, HongJoonLee, ChorongJang, Ho-ShikKim, , Young-JinCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 12 483-489 (7 pages)

YoungSunKim, HongJoonLee, ChorongJang, Ho-ShikKim, , Young-JinCho 저
...
- 3,000원
Despite the potential importance of the human regulator of calcineurin 1 (RCAN-1) gene in the modulation of cell survival under stress, little is known about its role in death-inducing signal pathways. In this study, we addressed the effects of RCAN1.4 knockdown on cellular susceptibility to apoptosis and the activation of death pathway proteins. Transfection of siRNAs against RCAN1.4 resulted in enhanced Fas- and etoposide-induced apoptosis, which was associated with increased expression and...
122.

Inhibition of β-amyloid1-40 Peptide Aggregation and Neurotoxicity by Citrate

YongHoonPark, Young-JinKim, IlHongSon, HyunDukYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 2 273-279 (7 pages)

YongHoonPark, Young-JinKim, IlHongSon, HyunDukYang 저
...
- 3,000원
a concentration- dependent manner (Th-T intensity: from 91.3% in 0.01 mM citrate to 82.1% in 1.0 mM citrate vs. 100.0% in AՂ1-40 alone). In cytotoxicity and viability assays, citrate reduced the toxicity of AՂ1-40 in a concentration-dependent manner, in which the cytotoxicity decreased from 107.5 to 102.3% as compared with AՂ1-40 aggregates alone treated cells (127.3%) and the cell viability increased from 84.6 to 93.8% as compared with the AՂ1-40 aggregates alone treated...
123.

Water Extract of Samultang Reduces Apoptotic Cell Death by H2O2-Induced Oxidative Injury in SK-N-MC Cells

GyoungWanLee, MinSunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 1 139-145 (7 pages)

GyoungWanLee, MinSunKim 저
...
- 3,000원
Chinese herb, on apoptotic cell death by H2O2-induced oxidative stress in SK-N-MC cells. A nuclear fragmentation was observed via fluorescence imaging 12 h after exposure to 30</SUB>ՌM H2O2 and DNA laddering was detected via agarose electrophoresis gel. In addition, increases in sub-G1 phase and cleavage of the PARP protein were observed. However, treatment with SMT for 2 h prior to H2O2 exposure significantly reduced apoptotic cell death induced by incubation with 30ՌM H2O2 in...
124.

Roles of ERK and NF-κB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells

Seung-HunKang, Ji-HyukLee, Kyung-HaChoi, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 7 171-176 (6 pages)

Seung-HunKang, Ji-HyukLee, Kyung-HaChoi, Byung-YongRhim, KoanhoiKim 저
...
- 3,000원
stress stimuli. The aim of this article is to investigate whether HSP22 affects IL-8 expression in vascular smooth muscle cells (VSMCs), and which cellular factors are involved in the HSP-mediated IL-8 induction in that cell type in terms of mitogen activated protein kinase (MAPK) and transcription element. Exposure of aortic smooth muscle cells (AoSMCs) to HSP22 not only enhanced IL-8 release but also induced IL-8 transcript via promoter activation. HSP22 activated ERK and p38 MAPK in AoSMCs....
125.

Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population

DongHeeHan, SuKangKim, SungwookKang, Bong-KeunChoe, KeonSikKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 6 125-128 (4 pages)

DongHeeHan, SuKangKim, SungwookKang, Bong-KeunChoe, KeonSikKim, Joo-HoChung 저
...
- 1,500원
The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on...
126.

Gene Expression Profile in Microglia following Ischemia- Reperfusion Injury

JuHyeonOh, HyungSooHan, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 2 173-180 (8 pages)

JuHyeonOh, HyungSooHan, JaeSikPark 저
...
- 3,000원
Microglial activation is thought to play a role in the pathogenesis of many brain disorders. Therefore, understanding the response of microglia to noxious stimuli may provide insights into their role in disorders such as stroke and neurodegeneration. Many genes involved in this response have been identified individually, but not systematically. In this regards, the microarray system permitted to screen a large number of genes in biological or pathological processes. Therefore, we used microarray...
127.

The Effects of DTBNP on Intracellular Ca2+ Signaling in Cultured Bovine Aortic Endothelial Cells

SungJinPark, ByungJooKim, MeiHongZhu, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 5 341-346 (6 pages)

SungJinPark, ByungJooKim, MeiHongZhu, InsukSo, KiWhanKim 저
...
- 3,000원
The mechanism underlying oxidant-induced intracellular Ca2+ ([Ca2+]i) increase was studied in cultured bovine aortic endothelial cells (BAECs) using fura-2 AM. In the presence of 2 mM extracellular Ca2+, the application of DTBNP (20μM), a membrane-permeable oxidant, caused an increase in [Ca2+]i, and DTT (2 mM) as a reductant completely reversed the effect of DTBNP. The [Ca2+]i increase induced by DTBNP was also observed in an extracellular Ca2+-free/2 mM EGTA solution, indicating the release...
128.

Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes

SunghyunKang, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, HyungkyuKim, DangVanCuong, TaehoKim, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 6 291-298 (8 pages)

SunghyunKang, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, HyungkyuKim, DangVanCuong, TaehoKim, EuiyongKim, JinHan 저
...
- 3,000원
AM fluorescence intensity. When sarcoplasmic reticulum (SR) Ca2⁢ was depleted by 1μM thapsigargin plus 10μM ryanodine, the initial increase of Fluo-4 AM fluorescence intensity was unaffected, however, the subsequent progressive increase was abolished. KB-R7943 delayed both the first and the second phases of cytosolic Ca2⁢ overload, while Na⁢-free solution accelerated the second. The above results suggest that: 1) the initial rise in cytosolic Ca2⁢ under DNP results from...
129.

Enhanced Expression of Cell Adhesion Molecules in the Aorta of Diabetic Mice is Mediated by gp91phox-derived Superoxide

MiRanYun, JongJaeKim, SunMiLee, HyeJinHeo, SunSikBae, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 6 109-116 (8 pages)

MiRanYun, JongJaeKim, SunMiLee, HyeJinHeo, SunSikBae, ChiDaeKim 저
...
- 3,000원
Endothelial activation and subsequent recruitment of inflammatory cells are important steps in atherogenesis. The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying mechanisms remain unclear. To determine the relationship among vascular production of superoxide, expression of CAM and diabetes, superoxide generation and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E- and...
130.

Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex

Hwang-SooKim, Hyun-SokKim, SangJuneHahn, Myung-JunKim, ShinHeeYoon, Yang-HyeokJo, Myung-SukKim, Duck-JooRhie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 1 295-300 (6 pages)

Hwang-SooKim, Hyun-SokKim, SangJuneHahn, Myung-JunKim, ShinHeeYoon, Yang-HyeokJo, Myung-SukKim, Duck-JooRhie 저
...
- 3,000원
by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 (50μM), an NMDA receptor antagonist. Whereas bath application of 5-HT (10μM) inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine (PCA, 10μM), for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and 10μM) suppressed the induction of LTP in concentration-dependent manner, however,...

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