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121.

Effects of Noradrenaline on the Membrane Potential of Prostatic Neuroendocrine Cells of Rat

JunHeeKim, SunYoungShin, Dae-YongUhm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 9 47-52 (6 pages)

JunHeeKim, SunYoungShin, Dae-YongUhm, SungJoonKim 저
...
- 3,000원
transient hyperpolarization and subsequent fluctuation at around ⁣40 mV on application of NA. Under voltage clamp conditions (holding voltage, ⁣40 mV) with CsCl pipette solution, NA evoked a slight inward current (＜⁣20 pA). NA induced a sharp increase of cytosolic Ca2⁢ concentration ([Ca2⁢]c), measured by the fura-2 fluorescence, and the voltage clamp study showed the presence of charybdotoxin-sensitive Ca2⁢-activated K⁢ currents. In summary, adrenergic...
122.

Thiol-dependent Redox Mechanisms in the Modification of ATP-Sensitive Potassium Channels in Rabbit Ventricular Myocytes

JinHan, NariKim, DangVanCuong, ChunghuiKim, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 4 15-23 (9 pages)

JinHan, NariKim, DangVanCuong, ChunghuiKim, EuiyongKim 저
...
- 3,000원
Cellular redox state is known to be perturbed during ischemia and that Ca2⁢ and K⁢ channels have been shown to have functional thiol groups. In this study, the properties of thiol redox modulation of the ATP-sensitive K⁢ (KATP) channel were examined in rabbit ventricular myocytes. Rabbit ventricular myocytes were isolated using a Langendorff column for coronary perfusion and collagenase. Single-channel currents were measured in excised membrane patch configuration of...
123.

Effects of Kanagawa Hemolysin on Blood Pressure and Arterial Tone in Rats

YoungMoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 8 225-233 (9 pages)

YoungMoonKim 저
...
- 3,000원
Kanagawa hemolysin (KH), an exotoxin produced from Kanagawa phenomenon-positive Vibrio parahemolyticus, has been shown to possess various biological activities including hemolysis, enterotoxicity, cytotoxicity, and cardiotoxicity. The aim of this study was to investigate the effect of KH on the cardiovascular system and its mechanism, employing in vivo and in vitro experiments of the rat. Intracerebroventricular (icv) administration of 100 mHU KH produced a marked and continuous pressor effect...
124.

Differential Changes of ATP-sensitive Potassium Channel Current after Hypoxia-reperfusion Treatment in Mouse Neuroblastoma 2a (N2a) Cell

Ji-HoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 2 183-186 (4 pages)

Ji-HoPark 저
...
- 1,500원
Ischemic damage is one of the most serious problems. The openers of KATP channel have been suggested to have an effect to limit the ischemic damage. However, it is not yet clear how KATP channels of a cell correspond to hypoxic damage. To address the question, N2a cells were exposed to two different hypoxic conditions as follows: 6 hours hypoxia followed by 3 hours reperfusion and 12 hours hypoxia followed by 3 hours reperfusion. As the results, 6 hours hypoxic treatment increased...
125.

Congenital LQT Syndromes From Gene to Torsade de Pointes

EdwardCarmeliet 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.1 1 1-8 (8 pages)

EdwardCarmeliet 저
...
- 3,000원
Congenital Long QT syndrome (LQTs) is a relatively rare pathologic disorder but results frequently in sudden cardiac death. Of the six LQTs that have been clinically described, five have been worked out for their genetic and biophysical profile. Most are generated by mutations which cause a loss of function in two delayed K⁢currents, iKs and iKr. One syndrome is generated by mutations in the Na⁢ channel which causes essentially a gain of function in the channel. Clinically the...
126.

Forward-Mode Na+-Ca2+ Exchange during Depolarization in the Rat Ventricular Myocytes with High EGTA

Eun-GiKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 5 487-494 (8 pages)

Eun-GiKim, ChangMannKo 저
...
- 3,000원
During depolarization, extrusion of Ca2⁢ from sarcoplasmic reticulum through forward-mode Na⁢-Ca2⁢ exchange was studied in the rat ventricular myocytes patch-clamped in whole-cell configuration. In order to confine the Ca2⁢ responses in a micro-domain by limiting the Ca2⁢ diffusion time, rat ventricular myocytes were dialyzed with high (14 mM) EGTA. K⁢ current was suppressed by substituting KCl with 105 mM CsCl and 20 mM TEA in the pipette filling solution...
127.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2⁢ leading to activation of Ca2⁢/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different...
128.

Effect of Propofol on Ion Channels in Acutely Dissociated Dorsal Raphe Neuron of Sprague-Dawley Rats

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 10 189-197 (9 pages)

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 저
...
- 3,000원
To investigate propofol's effects on ionic currents induced by γ-aminobutyric acid (GABA) and glycine as well as on those produced by the nicotinic acetylcholine- and glutamate-responsive channels, rat dorsal raphe neurons were acutely dissociated and the nystatin-perforated patch-clamp technique under voltage- clamp conditions was used to observe their responses to the administration of propofol. Propofol evoked ion currents in a dose-dependent manner, and propofol (10⁣4 M) was used to...
129.

The Alteration of Ca2+-activated K+ Channels in Coronary Arterial Smooth Muscle Cells Isolated from Isoproterenol-induced Cardiac Hypertrophy in Rabbit

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 5 147-156 (10 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
It has been proposed that Ca2⁢-activated K⁢ (KCa) channels play an essential role in vascular tone. The alterations of the properties of coronary KCa channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present studies were carried out to determine the properties of coronary KCa channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique....
130.

Zn2+ Modulates the Responses of Rat Dorsal Horn Neuron to C-Fiber Stimulation and Excitatory Amino Acids

ChangHoonAhn, HongKeeShin, JinHyukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 3 445-453 (9 pages)

ChangHoonAhn, HongKeeShin, JinHyukKim 저
...
- 3,000원
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation- and nerve injury-induced hyperalgesia in the behavioral test. In this study, we investigated the effects of zinc on the responses of dorsal horn cells to NMDA, kainate and graded electrical stimulation of...

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