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- 대한생리학회-대한약리학회(42)
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- 신경정신의학(41)
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전체 선택해제
총 201건 검색
본문검색 결과만 보기
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Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
HongZhang, FanAn, LiTang, RongguoQiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 4 109-120 (12 pages)
The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster. This study investigated the effects of UTD2 on the actin cytoskeleton and its critical regulators, and the signaling pathways which are essential for cell motility, growth and survival in MCF-7 breast cancer cells. Results showed that UTD2 inhibited the cellular functions of actin... -
Regulation of Ba2+-Induced Contraction of Murine Ureteral Smooth Muscle
YoungChulKim, MooYeolLee, Wun-JaeKim, SoonChulMyung, WoongChoi, ChanHyungKim, Wen-XieXu, SeungRyulKim6, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 7 207-213 (7 pages)
This study was designed to characterize ureteral smooth muscle motility and also to study the effect of forskolin (FSK) and isoproterenol (ISO) on smooth muscle contractility in murine ureter. High K+ (50 mM) produced tonic contraction by 0.17±0.06 mN (n=19). Neuropeptide and neurotransmitters such as serotonin (5μM), histamine (20μM), and carbarchol (CCh, 10∼50μM) did not produce significant contraction. However, CCh (50μM) produced slow phasic contraction in the presence of 25 mM K+.... -
Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death
MoonHyunBu, KyeongAhLee, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 1 315-322 (8 pages)
if secreted TNF-α was functional. Conditioned medium activated ERK and p38 MAPK pathways and induced MMP-9 expression, whereas depletion of the cytokine with its soluble receptor (sTNFR) remarkably inhibited induction of MMP-9 by conditioned medium. These findings suggest that TNF-α in conditioned medium seems to be active. Then, contribution of TNF-α on death-inducing activity of conditioned medium was examined. Depletion of TNF-α with soluble TNF-α receptor decreased the death activity of... -
Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes
Kyung-BongYoon, Sung-WanAhn, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 6 101-110 (10 pages)
and by Na-depletion. The other was identified by 5 mM NiCl2 after suppression of ICaL and ryanodine receptor, constituting 14.8⁑1.6%. This latter was blocked by either 10 mM caffeine-induced SR Ca2-depletion or 1 mM tetracaine. IV-relationships illustrated that the latter was activated until the peak in 30∼35 mV lower voltages than the former. Overall, it was concluded that the SR Ca2 release process in the rat ventricular myocytes is mediated by the voltage-sensitive... -
Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts
Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)
A large number of factors such as osteotropic hormones, cytokines, or growth factors are related to the bone remodeling which is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Recent investigations have indicated that cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) play a potential role in the bone resorption associated with a variety of pathological conditions such as inflammatory osteolytic disease.... -
G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle
UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)
A functional linkage between G13, RhoA, ROCK, PKC-ε, CPI-17 and MLC phosphorylation in sustained contraction has been implicated. Contraction of normal esophageal circular muscle (ESO) in response to acetylcholine (ACh) is linked to M2 muscarinic receptors activating at least three intracellular phospholipases, i.e. phosphatidylcholine-specific phospholipase C (PC-PLC), phospholipase D (PLD) and the high molecular weight (85 kDa) cytosolic phospholipase A2 (cPLA2) to induce phosphatidylcholine... -
Fragile Self and Malevolent Others
Hye Yoon Park, Minji Bang, Kyung Ran Kim, Eun Lee, Suk Kyoon An 대한신경정신의학회 Psychiatry Investigation 9 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 8 796-804 (9 pages)
Objective_Biased attribution styles of assigning hostile intention to innocent others and placing the blame were found in schizophrenia. Attribution styles in individuals at ultra-high risk (UHR) for psychosis, however, have been less studied especially for its association with various psychological factors. We investigated whether UHR individuals show increased hostility perception and blaming bias and explored the associations of these biased styles of attribution with the factor structure of... -
Methylphenidate 투약에 따른 주의력결핍 과잉운동장애 아동의 청각 사건관련전위의 변화
최보문, 성양숙, 한상익, 이성필 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 2호 7 281-291 (11 pages)
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정신분열병 치료효과에 대한 신경인지기능의 예측력에 관한 연구
오병훈, 이희상, 최의헌, 현명호, 조현상, 유계준 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 6 1065-1073 (9 pages)
연구목적： 신경인지기능검사가 정신분열병 환자의 예후 및 치료에 대한 반응을 예측할 수 있는 인자로 작용할 수 있 다는 연구결과들이 있었다. 이들 연구에서는 인지기능을 측정하는 검사도구 중 일부를 이용하여 치료결과를 예측해 본 것이므로 저자들은 보다 광범위한 신경인지기능검사를 이용하여 이들 중 어떤 검사결과가 정신분 열병 환자들에 대한 치료결과를 얼마나 예측해 줄 수 있는지를 알아보기 위해 본 연구를 수행하였다. 방 법： 연구대상은 DSM-Ⅳ 진단기준에 의거 정신분열병으로 진단된 입원 환자 33명을 대상으로... -
알쯔하이머형 치매 환자의 단핵세포 증식과 싸이토카인 생성에 대한 β-아밀로이드 펩티드의 작용
채정호, 백인호 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 1호 17 190-200 (11 pages)
연구목적： 알쯔하이머 치매의 병인론에 면역성 기전이 개입된다는 가설을 확인하고자 본 연구를 행하였다. 방 법： 알쯔하이머 치매 19명, 혈관성 치매 22명, 정상 노인 19명에서 말초 혈액 단핵세포를 분리하여 phytohemagglutinin- P(PHA-P) 및 1-40의 β-아밀로이드(Aβ)로 자극하여 세포 증식 정도를 비교하였으며, 배양 상청액에서 interleukin-1β(IL-1β)와 tumor necrosis factor-α(TNF-α)를 효소결합면역흡착분석법 으로 측정하였다. 결 과： 1) PHA-P 자극에 의한 단핵 세포의 증식은 세 군에서 차이가 없었다. 2) Aβ...
