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151.

Inhibition of NF-κB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death

JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 3 65-71 (7 pages)

JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 저
...
- 3,000원
Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a mouse brain endothelioma-derived cell line, bEnd.3, and oxygen-glucose deprivation (OGD) as an in vitro stroke model, the role of nuclear factor kappa B (NF-κB) activation during ischemic injury was investigated. OGD was found to activate NF-κB and to induce bEnd.3 cell death in a...
152.

Mechanism of Glutamate-induced [Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats

SungJunJung, JeongSookChoi, JiyeonKwak, JunKim, JongWhanKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 1 53-57 (5 pages)

SungJunJung, JeongSookChoi, JiyeonKwak, JunKim, JongWhanKim, SangJeongKim 저
...
- 1,500원
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellular Ca2⁢ concentration ([Ca2⁢]i) and induces cytotoxicity. In the present study, we investigated whether the glutamate-induced [Ca2⁢]i increase was associated with the activation of ionotropic (iGluR) and metabotropic GluRs (mGluR) in substantia gelatinosa neurons, using spinal cord slice of juvenile rats...
153.

Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 8 39-45 (7 pages)

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 저
...
- 3,000원
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level measured as thiobarbituric acid reactive substances, the vasorelaxation of isolated thoracic aorta and the iNOS expression in kidney of streptozotocin induced diabetic rats. Sprague Dawley rats were divided into four groups: control, ascorbate (400 mg/kg rat weight daily in drinking water),...
154.

4-Aminopyridine Inhibits the Large-conductance Ca2+-activated K+ Channel (BKCa) Currents in Rabbit Pulmonary Arterial Smooth Muscle Cells

YoungMinBae, AeranKim, BokyungKim, Sung-IlCho, JunghwanKim, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 5 25-28 (4 pages)

YoungMinBae, AeranKim, BokyungKim, Sung-IlCho, JunghwanKim, YungEEarm 저
...
- 1,500원
Ion channel inhibitors are widely used for pharmacological discrimination between the different channel types as well as for determination of their functional role. In the present study, we tested the hypothesis that 4-aminopyridine (4-AP) could affect the large conductance Ca2⁢-activated K⁢ channel (BKCa) currents using perforated-patch or cell-attached configuration of patch-clamp technique in the rabbit pulmonary arterial smooth muscle. Application of 4-AP reversibly inhibited the...
155.

Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes

Han-JungChae, Hyun-KiKim, Wan-KuLee, Soo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 7 319-325 (7 pages)

Han-JungChae, Hyun-KiKim, Wan-KuLee, Soo-WanChae 저
...
- 3,000원
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-γ or TNF-α/ IFN-γ) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-κB transcriptional factor in primary neonatal cardiomyocytes. When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-γ or TNF-α/IFN-γ) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB203580 inhibited...
156.

Involvement of NMDA Receptor and L-type Calcium Channel in the Excitatory Action of Morphine

BonSeopKoo, HongKeeShin, SukHanKang, JongHunJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 2 241-246 (6 pages)

BonSeopKoo, HongKeeShin, SukHanKang, JongHunJun 저
...
- 3,000원
We studied the excitatory action of morphine on the responses of dorsal horn neuron to iontophoretic application of excitatory amino acid and C-fiber stimulation by using the in vivo electrophysiological technique in the rat. In 137 of the 232 wide dynamic range (WDR) neurons tested, iontophoretic application of morphine enhanced the WDR neuron responses to N-methyl-D-aspartate (NMDA), kainate, and graded electrical stimulation of C-fibers. Morphine did not have any excitatory effects on the...
157.

Neuronal Activity of the Vestibular Nuclei Following Acute Hypotension in Rats

ByungRimPark, MinSunKim, KumHyunBaik, MoonYoungLee, MyungAeChoi, JaeHyoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 5 199-206 (8 pages)

ByungRimPark, MinSunKim, KumHyunBaik, MoonYoungLee, MyungAeChoi, JaeHyoLee 저
...
- 3,000원
The role of peripheral vestibular receptors in acute hypotension was investigated in anesthetized rats. Acute hypotension was induced by either intravenous infusion of sodium nitroprusside (SNP) or by experimental hemorrhage, and electrical activity and expression of cFos-like immunoreactive (cFL) protein were measured in the medial vestibular nuclei (MVN). Blood pressure decreased proportionately to the does of intravenous SNP and to the volume of the hemorrhage. Blood pressure decreased 10,...
158.

Decreased Expression of Aquaporin-2 Water Channels in the Kidney in Rats Treated with Reserpine

JongUnLee, YoonWhaOh, SunmiKim, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 3 307-313 (7 pages)

JongUnLee, YoonWhaOh, SunmiKim, SooWanKim 저
...
- 3,000원
Whether there exists a sympathetic neural mechanism regulating the expression of aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats were treated with reserpine (1 mg/kg, IP), and the expression of AQP1-4 proteins was determined in the kidney one day thereafter. Following the treatment with reserpine, the systolic blood pressure measured in a conscious state was significantly decreased in the experimental group compared with that in the control (83⁑8 vs...
159.

The Alteration of Ca2+-activated K+ Channels in Coronary Arterial Smooth Muscle Cells Isolated from Isoproterenol-induced Cardiac Hypertrophy in Rabbit

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 5 147-156 (10 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
It has been proposed that Ca2⁢-activated K⁢ (KCa) channels play an essential role in vascular tone. The alterations of the properties of coronary KCa channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present studies were carried out to determine the properties of coronary KCa channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique....
160.

Modulation of L-type Ca2+ Channel Currents by Various Protein Kinase Activators and Inhibitors in Rat Clonal Pituitary GH3 Cell Line

YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 4 139-146 (8 pages)

YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 저
...
- 3,000원
L-type Ca2⁢ channels play an important role in regulating cytosolic Ca2⁢ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type Ca2⁢ channel currents in rat pituitary GH3 cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and...

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