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161.

Expression of Ca2+-activated K+ Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 3 51-58 (8 pages)

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 저
...
- 3,000원
Cardiac fibroblasts constitute one of the largest cell populations in the heart, and contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, their cardiac functions, especially electrophysiological properties, have often been disregarded in studies. Ca2+-activated K+ (KCa) channels can control Ca2+ influx as well as a number of Ca2+-dependent physiological processes. We, therefore, attempted to identify and characterize KCa channels in rat...
162.

Lysophosphatidylcholine Increases Ca2+ Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells

SeungsooJung, YounghoLee, SungsikHan, YoungwhanKim, TaiksangNam, DucksunAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 5 31-34 (4 pages)

SeungsooJung, YounghoLee, SungsikHan, YoungwhanKim, TaiksangNam, DucksunAhn 저
...
- 1,500원
Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase A2, has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. Ca2+ influx was shown to be augmented in atherosclerotic artery which might be responsible for abnormal vascular reactivity. However, the mechanism underlying Ca2+ influx change in atherosclerotic artery remains undetermined. The purpose of the present study was to examine the effects of LPC on...
163.

Roles of Dopaminergic D1 and D2 Receptors in Catecholamine Release from the Rat Adrenal Medulla

YoungJooBaek, YooSeongSeo, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 3 13-24 (12 pages)

YoungJooBaek, YooSeongSeo, DongYoonLim 저
...
- 4,100원
The aim of the present study was designed to establish comparatively the inhibitory effects of D1-like and D2-like dopaminergic receptor agonists, SKF81297 and R(-)-TNPA on the release of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. SKF81297 (30ՌM) and R-(-)-TNPA (30ՌM) perfused into an adrenal vein for 60 min, produced great inhibition in the CA secretory responses evoked by ACh...
164.

Regulation of Ba2+-Induced Contraction of Murine Ureteral Smooth Muscle

YoungChulKim, MooYeolLee, Wun-JaeKim, SoonChulMyung, WoongChoi, ChanHyungKim, Wen-XieXu, SeungRyulKim6, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 7 207-213 (7 pages)

YoungChulKim, MooYeolLee, Wun-JaeKim, SoonChulMyung, WoongChoi, ChanHyungKim, Wen-XieXu, SeungRyulKim6, SangJinLee 저
...
- 3,000원
This study was designed to characterize ureteral smooth muscle motility and also to study the effect of forskolin (FSK) and isoproterenol (ISO) on smooth muscle contractility in murine ureter. High K+ (50 mM) produced tonic contraction by 0.17±0.06 mN (n=19). Neuropeptide and neurotransmitters such as serotonin (5μM), histamine (20μM), and carbarchol (CCh, 10∼50μM) did not produce significant contraction. However, CCh (50μM) produced slow phasic contraction in the presence of 25 mM K+....
165.

Influence of SKF81297 on Catecholamine Release from the Perfused Rat Adrenal Medulla

Deok-HoChoi, Jong-HeeCha, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 6 197-206 (10 pages)

Deok-HoChoi, Jong-HeeCha, Dong-YoonLim 저
...
- 3,000원
The aim of the present study was to investigate the effects of 6-chloro-7,8-dihydroxy-1-phenyl-2,3, 4,5-tetrahydro-1H-3-benzazepine (SKF81297), a selective agonist of dopaminergic D1 receptor, on the secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused rat adrenal gland, and also to elucidate the mechanism involved. SKF81297 (10∼100μM) perfused into an adrenal vein for 60 min produced dose- and time-dependent inhibition of CA...
166.

Alternative Isoforms of TonEBP with Variable N-termini are Expressed in Mammalian Cells

HyoShinKim, SookJinSon, SeonNyoKim, YongDukKim, KwangJinKim, ByeongHwaJeon, JinBongPark, SangDoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 9 135-138 (4 pages)

HyoShinKim, SookJinSon, SeonNyoKim, YongDukKim, KwangJinKim, ByeongHwaJeon, JinBongPark, SangDoLee 저
...
- 1,500원
Hypertonicity imposes a great deal of stress to cells since it causes rise in cellular ionic strength, which can be reduced by the accumulation of compatible osmolytes. TonEBP plays a central role in the cellular accumulation of compatible osmolytes via transcriptional stimulation of membrane transporters and aldose reductase. Alternatively spliced forms of TonEBP mRNA have previously been reported and two of them showed different transcriptional activity. In the present study, isoform-specific...
167.

Gene Expression Profile in Microglia following Ischemia- Reperfusion Injury

JuHyeonOh, HyungSooHan, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 2 173-180 (8 pages)

JuHyeonOh, HyungSooHan, JaeSikPark 저
...
- 3,000원
Microglial activation is thought to play a role in the pathogenesis of many brain disorders. Therefore, understanding the response of microglia to noxious stimuli may provide insights into their role in disorders such as stroke and neurodegeneration. Many genes involved in this response have been identified individually, but not systematically. In this regards, the microarray system permitted to screen a large number of genes in biological or pathological processes. Therefore, we used microarray...
168.

Neuroprotective Effects of Lithium on NMDA-induced Excitotoxicity in Mouse Cerebrum

Gee-younKwon, Soo-kyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 1 111-122 (12 pages)

Gee-younKwon, Soo-kyungKim 저
...
- 4,100원
Neuroprotective properties of lithium were evaluated by using in vivo NMDA excitotoxicity model. Systemic injection of NMDA to young mice induced neuronal apoptosis mediated by both TNFR-1 and Fas ligand, and long-term lithium treatment showed noticeable neuroprotection against NMDA-induced excitotoxicity: NMDA-damaged neurons expressed several apoptosis-related gene products such as TNFR-1, Fas ligand, and caspase-3, and these gene expressions were not found in the brain of mice chronically...
169.

Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 6 31-38 (8 pages)

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 저
...
- 3,000원
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several receptors. Employing whole-cell patch clamp techniques in rat brain slice, we studied the effects of fluoxetine on corticostriatal synaptic transmission by measuring the change in spontaneous excitatory postsynaptic currents (sEPSC). Acute treatment of rat brain slice with fluoxetine (10μM)...
170.

Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes

HaifengZheng, JaeHongKo, JooHyunNam, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 4 19-24 (6 pages)

HaifengZheng, JaeHongKo, JooHyunNam, YungEEarm, SungJoonKim 저
...
- 3,000원
The intermediate conductance Ca2⁢-activated K⁢ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was compared between Bal-17 and WEHI-231 cell lines which represent mature and immature stages of murine B lymphocytes, respectively. The whole-cell patch clamp with high-Ca2⁢ (0.8μM) KCl pipette solution revealed a voltage-independent K⁢ current that was blocked...

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