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전체 선택해제
총 49건 검색
본문검색 결과만 보기
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New Cytotoxic Sulfated Saponins from the Starfish Certonardoa semiregularis
Wang. Wei Hong, Jang. Hyo Jin, Hong. Jong Ki, Lee. Chong Ok, Bae. Song Ja, Shin. Sook, Jung. Jee H. 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2005, Vol.28 No.3 285-289 (5 pages)
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국내외에서 운영되는 음악 급수시험제도 비교연구
권수미(Su Mi Kwon), 정완규(Wan Kyu Chung) 한국음악교육학회 음악교육연구 31 Pages
한국음악교육학회 음악교육연구 2014, 제 43권 제 4호 2 25-55 (31 pages)
본 연구는 국내에서 운영되는 한국학원연합회 산하 음악교육협의회에서 주관하는 음악급수제도의 현황을 파악하여 올바른 음악평가제도가 국내에서 정착될 수 있는 학문적인 기반을 제공하는 것을 연구목적으로 한다. 이를 위하여 국외에서 운영되는 음악급수제도 중 국제적으로 신뢰받고 있는 영국의 ABRSM과 미국의 NYSSMA의 음악급수제도 중 가장 많은 학습자들이 지원하는 피아노부분을 연구대상으로 선정하였다. 이들 기관에서 운영하는 급수제도의 역사와 배경, 구성, 평가내용 및 방법 등을 문헌조사를 통하여 비교 분석해... -
생명과학 학습에서 디지털 콘텐츠의 유형에 따라 생성된 과학적 의문의 분석
권승혁, 엄증태, 권용주 한국교원대학교 뇌기반교육연구소 Brain & Learning 11 Pages
한국교원대학교 뇌기반교육연구소 Brain & Learning 2014, 제 4권 제 2호 1 1-11 (11 pages)
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Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
HongZhang, FanAn, LiTang, RongguoQiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 4 109-120 (12 pages)
The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster. This study investigated the effects of UTD2 on the actin cytoskeleton and its critical regulators, and the signaling pathways which are essential for cell motility, growth and survival in MCF-7 breast cancer cells. Results showed that UTD2 inhibited the cellular functions of actin... -
Multiple Residues in the P-Region and M2 of Murine Kir 2.1 Regulate Blockage by External Ba2＋
YoungMeeLee, GarethA.Thompson, IanAshmole, MarkLeyl, InsukSo, PeterR.Stanfield 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 10 61-69 (9 pages)
We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on Ba2＋ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary (CHO) cells and used the whole cell patch-clamp technique to record K＋ currents in the absence and presence of externally applied Ba2＋. Wild type Kir2.1 was blocked by externally applied Ba2＋ in a voltage and concentration dependent manner. Mutants... -
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation... -
Mechanism of Membrane Hyperpolarization by Extracellular K+ in Resistance-sized Cerebral Arterial Muscle Cell of Rabbit
SeHoonKim, KunMooChoi, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 1 1-10 (10 pages)
We sought to find out the mechanism of vascular relaxation by extracellular K concentration ([K]o) in the cerebral resistant arteriole from rabbit. Single cells were isolated from the cerebral resistant arteriole, and using voltage-clamp technique barium-sensitive K currents were recorded, and their characteristics were observed. Afterwards, the changes in membrane potential and currents through the membrane caused by the change in [K]o was observed. In the smooth... -
토끼 단일 심근세포에서 대사억제시 Inward Rectifier(IK1)의 변화 Effect of Metabolic Inhibition on Inward Rectifier K Current in Single Rabbit Ventricular Myocytes
정유정, 호원경, 엄융의, YuJeongChung, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 15 741-748 (8 pages)
In the present study, we have investigated the effect of metabolic inhibition on the inward rectifier K current (IK1). Using whole cell patch clamp technique we applied voltage ramp from 80 mV to 140 mV at a holding potential of 30 mV and recorded the whole cell current in single ventricular myocytes isolated from the rabbit heart. The current-voltage relationship showed N-shape (a large inward current and little outward current with a negative slope) which is a...
