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201.

Effects of Phenylephrine on the Excitability of Medial Vestibular Nuclear Neurons in Rats

Han-SeongJeong, HaeRyongHuh, Myung-JooJang, Seol-HeeHong, SujeongJang, JinPark, Seung-HanLee, Jae-HaKim, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 3 131-136 (6 pages)

Han-SeongJeong, HaeRyongHuh, Myung-JooJang, Seol-HeeHong, SujeongJang, JinPark, Seung-HanLee, Jae-HaKim, Jong-SeongPark 저
...
- 3,000원
used. After enzymatic digestion, dissociated medial vestibular neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous action potentials were recorded by standard patch-clamp techniques. In current-clamp mode, the frequency of spontaneous action potential of medial vestibular nuclear neurons was decreased by phenylephrine (n=15). Phenylephrine increased the amplitude of afterhyperpolarization without changes in the resting membrane potential and spike...
202.

Effects of Pharmacological Modulators of Ca2+-activated K+ Channels on Proliferation of Human Dermal Fibroblast

JihyunYun, TaehoKim, SoonchulMyung, HyoweonBang, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 6 95-100 (6 pages)

JihyunYun, TaehoKim, SoonchulMyung, HyoweonBang, InjaLim 저
...
- 3,000원
about ⁣40 mV stepped from a holding potential of ⁣70 mV. The amplitude of K⁢ current was increased by NS1619, a specific large-conductance Ca2⁢-activated K⁢ (BK) channel activator, but decreased by iberiotoxin (IBTX), a specific BK channel inhibitor. To investigate the presence of an intermediate-conductance Ca2⁢-activated K⁢ (IK) channels, we pretreated the fibroblasts with low dose of TEA to block BK currents, and added 1-EBIO (an IK activator). 1-EBIO...
203.

pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 2 7-12 (6 pages)

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 저
...
- 3,000원
rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of ⁣60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward current. Also, when the holding potentials were changed from ⁢20 mV to ⁣80 mV...
204.

Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes

SunghyunKang, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, HyungkyuKim, DangVanCuong, TaehoKim, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 6 291-298 (8 pages)

SunghyunKang, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, HyungkyuKim, DangVanCuong, TaehoKim, EuiyongKim, JinHan 저
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- 3,000원
200μM 2,4-dinitrophenol (DNP), and mitochondrial Ca2⁢, mitochondrial membrane potential (ΔΨm), and cytosolic Ca2⁢ were measured, using Rhod-2 AM, TMRE, and Fluo-4 AM fluorescent dyes, respectively, by Laser Scanning Confocal Microscopy (LSCM). Furthermore, the role of sarcolemmal Na⁢/Ca2⁢ exchange (NCX) in cytosolic Ca2⁢ efflux was studied in KB-R7943 and Na⁢-free normal Tyrode's solution (143 mM LiCl ). When DNP was applied to cells loaded with Fluo-4 AM,...
205.

The Role of Mitochondrial ATP-sensitive Potassium Channel on Intestinal Pacemaking Activity

ByungJooKim, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 4 209-214 (6 pages)

ByungJooKim, KiWhanKim 저
...
- 3,000원
using whole-cell patch clamp techniques. Under current clamp mode, at 10μM glibenclamide, there was no change in pacemaking activity of ICCs. At 30μM glibenclamide, an inhibitor of the ATP sensitive K⁢ channels, we could find two examples. If pacemaking activity of ICCs was irregulating, pacemaking activity of ICCs was changed into regulating and if in normal conditions, membrane potential amplitude was increased. At 50μM glibenclamide, the resting membrane potential was depolarized. At...
206.

The Effect of External Divalent Cations on Intestinal Pacemaking Activity

ByungJooKim, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 3 203-208 (6 pages)

ByungJooKim, KiWhanKim 저
...
- 3,000원
a mean amplitude of ⁣500⁑50 pA or 30⁑1 mV and the frequency of 18⁑2 cycles/min. Treatments of the cells with external 0 mM Ca2⁢ stopped pacemaking activity of ICC. In the presence of 2 mM Ca2⁢, 0 mM external Mg2⁢ depolarized the resting membrane potential, and there was no change in the frequency of pacemaking activity. However, 10 mM external Mg2⁢ decreased the frequency of pacemaking activity (6.75⁑1 cycles/min, n=5). We replaced external 2...
207.

Effects of a δ-opioid Agonist on the Brainstem Vestibular Nuclear Neuronal Activity of Rats

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 1 137-142 (6 pages)

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 저
...
- 3,000원
patch-clamp techniques. The spontaneous action potentials were increased by DADLE in 12 cells and decreased in 3 cells. The spike frequency and resting membrane potential of these cells were increased by DADLE. The depth of afterhyperpolarization was not affected by DADLE. The potassium currents were decreased in 20 cells and increased in 5 cells. These results suggest that DADLE increases the neuronal activity of the medial vestibular nuclear neurons by altering resting membrane potential.
208.

Modulation of Large Conductance Ca2+-activated K+ Channel of Skin Fibroblast (CRL-1474) by Cyclic Nucleotides

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 9 131-134 (4 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
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- 1,500원
potential and [Ca2⁢]i, consistent with the known properties of BKCa channels. BKCa channels in CRL-1474 were positively regulated by adenylate cyclase activator (10μM forskolin), 8-Br-cyclic AMP (300μM) or 8-Br-cyclic GMP (300μM). These results suggest that human skin fibroblasts (CR-1474) have typical BKCa channel and this channel could be modulated by c-AMP and c-GMP. The electrophysiological characteristics of fibroblasts might be used as the diagnostic clues for Alzheimer disease.
209.

TASK-1 Channel Promotes Hydrogen Peroxide Induced Apoptosis

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 9 63-67 (5 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
...
- 1,500원
and cytotoxicity assay was preformed using cell counting kit-8 (CCK-8). Cell survival rates were calculated using the cytotoxicity assay data and dose-response curve was fitted to the H2O2 concentration. Ionic currents were recorded in cell-attached mode. The bath solution was the normal Ringer solution and the pipette solution was high K⁢ solution. In HEK-293 cells expressing TREK-1, TREK-2, TASK-3, H2O2 induced cell death did not change in comparison to non-transfected HEK-293. In HEK-29...
210.

Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 8 55-62 (8 pages)

Hye-OckJang, Hyun-SupEom, Sung-BaeRoh, IlYun 저
...
- 3,000원
extract or 2μl of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the [Ca2⁢]i of the cultured osteoblast cells: 3μl of 0.1% dried crude extract and 2μl of 0.1% dried aqueous fraction significantly increased the [Ca2⁢]i of the cultured osteoblast cells (8⁓104) to the extent that it deserves a considerable attention. Furthermore, the crude extract and aqueous...

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