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2101.

사람 Neuroblastoma SH-SY5Y 세포주에서 Opiate 내성에 의한 c-myc 유전자 표현 The c-myc Expression on the Opioid Tolerance in Human Neuroblastoma SH-SY5Y Cells

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 10 691-697 (7 pages)

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 저
...
- 3,000원
The mechanisms underlying opiate tolerance and dependence are not fully understood. We used human neuroblastoma SH-SY5Y cells as a model system for studying effects of morphine tolerance and withdrawal on c-myc induction and cAMP levels. It has been reported that regulation of c-fos by acute and chronic morphine withdrawal is mediated through alterations in CREB transcription factor. In this study, we examined the effects of morphine tolerance on c-myc expression and cAMP concentrations. The...
2102.

Regulation of AQP-4 Water Channel Expression in the Brain during Development and by Ischemia

JinSupJung, HaeGyuKim, HaeRahnBae, DukJoonSuh, ParkHwanTae, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 4 495-504 (10 pages)

JinSupJung, HaeGyuKim, HaeRahnBae, DukJoonSuh, ParkHwanTae, SangHoLee 저
...
- 3,000원
Water transport is mediated by two distinct pathways, diffusional and channel-mediated water transport. The first molecular water channel was identified from human erythrocytes in 1992. Genetically-related proteins from other mammalian tissues have subsequently been identified to transport water, and the group is referred to as th "Aquaporins". Aquaporin-4 (AQP4) is most abundant in the brain, which may be involved in CSF reabsorption and osmoregulation. However, ontogeny and regulatory...
2103.

Association of Dexamethasone-induced Apoptosis and G1-Arrest of Human Leukemic CEM Cells with Polyamine Deficit

Sang-HyunChoi, Jung-AeLee, Yang-SeokChae, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 12 457-466 (10 pages)

Sang-HyunChoi, Jung-AeLee, Yang-SeokChae, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 저
...
- 3,000원
The effects of DFMO or/and putrescine on the dexamethasone-induced apoptosis of CEM cells were studied to investigate the role of polyamines in anti-leukemic glucocorticoid action. Dexamethasone- induced apoptosis was preceded by significant decreases of cellular polyamine contents and putrescine uptake activity. But DFMO produced decreases of putrescine and spermidine contents and marked increase of putrescine uptake activity, but did not induce apoptosis. However, dexamethasone and DFMO,...
2104.

[3H]Ryanodine Binding Sites of SR Vesicles of the Chicken Pectoral Muscle

Hyo-YungYun, Jong-RyeJeon, Jang-HeeHong, Gang-MinHur, Jae-HeunLee, Jeong-HoSeok* 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 4 377-384 (8 pages)

Hyo-YungYun, Jong-RyeJeon, Jang-HeeHong, Gang-MinHur, Jae-HeunLee, Jeong-HoSeok* 저
...
- 3,000원
chicken pectoral muscle. The chicken SR vesicles have two high molecular weight (HMW) protein bands as in eel SR vesicles on SDS PAGE. The HMW bands on SDS PAGE were found in the [3H] ryanodine peak fraction (Fr3-5) obtained from the purification step of the ryanodine receptor protein. Bmax and KD of the chicken [3H]ryanodine binding sites were 12.52 pmol/mg protein and 14.53 nM, respectively. Specific [3H]ryanodine binding was almost maximal at 50∼100 ՌM Ca2+, but was not increased by 5...
2105.

Spontaneous Electrical Activity in Cerebellar Purkinje Neurons of Postnatal Rats

SangChaeNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 2 355-366 (12 pages)

SangChaeNam 저
...
- 4,100원
Although cerebellar Purkinje cells display spontaneous electrical activity in vivo and in slice experiments, the mechanism of the spontaneous activity generation has not been clearly understood. The aim of this study was to investigate whether cerebellar Purkinje cells of postnatal rats generate spontaneous electrical activity without synaptic inputs. Dissociated cerebellar Purkinje cells were used for reducing synaptic inputs in the present study. Cerebellar Purkinje cells with dendrites were...
2106.

Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment A Quantitative Autoradiographic Study

Hae-YoungPark, Young-SookHong, Chan-WoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 6 161-167 (7 pages)

Hae-YoungPark, Young-SookHong, Chan-WoongPark 저
...
- 3,000원
This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of 3H-dihydroalprenolol (3H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of 3H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala....
2107.

Effect of Hemorrhage on mRNA Expressions of Renin, Angiotensinogen and AT1 Receptors in Rat Central and Peripheral Tissues

MiKyungLee, HakryulJo, Kyung-SoonKim, Eun-KyoungYang, Won-JungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 5 151-159 (9 pages)

MiKyungLee, HakryulJo, Kyung-SoonKim, Eun-KyoungYang, Won-JungLee 저
...
- 3,000원
In an attempt to investigate whether hemorrhage affects the gene expression of the renin-angioteusin system (RAS) components in the brain and peripheral angiotensin-generating tissues, changes in mRNA levels of the RAS components in response to hemorrhage were measured in conscious unrestrained rats. Wistar rats were bled at a rate of 3 ml/kg/min for 5 min, and then decapitated 7 h after hemorrhage. Levels of mRNA for renin, angiotensinogen and angiotensin II-AT1 receptor subtypes (AT1A and...
2108.

Lithium-induced Increase of Synaptosomal Uptake of Norepinephrine in Rat Brain

Young-WukCho, Seung-HoHan, Chang-JuKim, Byung-IlMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 2 127-133 (7 pages)

Young-WukCho, Seung-HoHan, Chang-JuKim, Byung-IlMin 저
...
- 3,000원
Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of affective disorder, the action mechanism of lithium ion remains still unknown. To explore the action mechanism of lithium in the brain, we examined the effects of lithium on the extrasynaptosomal concentrations of catecholamines and their...
2109.

Induction of Apoptosis by Bile Acids in HepG2 Human Hepatocellular Carcinoma Cells

JinHyenBaek, Jung-AeKim, Chang-MoKang, YongSooLee, Kyu-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 14 107-115 (9 pages)

JinHyenBaek, Jung-AeKim, Chang-MoKang, YongSooLee, Kyu-WonKim 저
...
- 3,000원
We studied the effects of bile acids on the induction of apoptosis in HepG2 human hepatocellular carcinoma cells. Treatment with either ursodeoxycholic acid (UDCA) or lithocholic acid (LCA) resulted in a dose- and time-dependent decrease in cell viability assessed by MTT assay. Both UDCA and LCA also induced genomic DNA fragmentation, a hallmark of apoptosis, indicating that the mechanism by which these bile acids induce cell death was through apoptosis. Cycloheximide, a protein synthesis...
2110.

Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells

SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)

SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 저
...
- 3,000원
in the Na+-independent uptake. Kinetic analysis indicated that Vmax was suppressed, but Km was not altered. The Na+-dependent phlorizin binding was also decreased in cisplatin-treated cells. However, the AMG efflux from preloaded cells was not apparently retarded by cisplatin treatment. These data indicate that the cisplatin treatment impairs Na+-hexose cotransporters in LLC-PK1 cells and suggest strongly that defects in transporter function at the luminal plasma membrane of the proximal tubular...

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