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221.

Increased Activity of Large Conductance Ca2+-Activated K+ Channels in Negatively-Charged Lipid Membranes

JinBongParkPanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 15 529-539 (11 pages)

JinBongParkPanDongRyu 저
...
- 4,000원
surface charge was predicted by a 3-barrier-2-site model of energy profile for the permeation of K⁢ ions. In conclusion, despite the differences in structure and fluidity of phospholipids in bilayers, the activities of maxi K channels in two charged membranes composed of PS or PI were strikingly similar and larger than those in bilayers of PE. These results suggest that the enhancement of conductance and Po of maxi channels is mostly due to negative charges in the phospholipid head groups.
222.

Molecular Pharmacological Interaction of Phenylbutazone to Human Neutrophil Elastase

KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 14 385-393 (9 pages)

KooilKang 저
...
- 3,000원
model of human neutrophil elastase, was structurally stable. A deeply situated active center was at the core area surrounded by hydrophobic amino acids. Directly neighboring the active site was one positively charged atom and two atoms carrying a negative charge, which enabled the enzyme and the drug to form a strong interaction. Phenylbutazone may form a binding, similar to a key & lock system to the atoms carrying opposite charges near the active site of the enzyme molecule. Furthermore,...
223.

Inhibitory Effect of Caffeine on Carbachol-Induced Nonselective Cationic Current in Guinea-Pig Gastric Myocytes

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 10 353-359 (7 pages)

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 저
...
- 3,000원
In gastrointestinal smooth muscle, muscarinic stimulation by carbachol (CCh) activates nonselective cation channel current (ICCh) which is facilitated by intracellular [Ca2⁢] increase. Caffeine is widely used in experiments to mobilize Ca2⁢ from intracellular stores. This study shows a strong inhibitory effect of caffeine on ICCh in guinea-pig gastric myocyte. In this study, the underlying mechanism of the inhibitory effect of caffeine was investigated. ICCh was completely...
224.

External pH Effects on Delayed Rectifier K+ Currents of Small Dorsal Root Ganglion Neuron of Rat

YoungHoKim, JungHyunHahn, InJaLim, SungkwonChung, HyoWeonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 4 165-172 (8 pages)

YoungHoKim, JungHyunHahn, InJaLim, SungkwonChung, HyoWeonBang 저
...
- 3,000원
Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H+ ion in the tissue surrounding neurons is changed. Variations in H+ concentration are known to alter the conduction and/of the gating properties of several types of ion channels. Several types of K+ channels are modulated by pH. In this study, the whole cell configuration of the patch clamp technique has been applied to the recording of the responses of change of external pH on the delayed...
225.

Discrepancy between in vitro and in vivo Effect of Gαs Gene Mutation on the mRNA Expression of TRH Receptor

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 13 101-108 (8 pages)

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 저
...
- 3,000원
strong and prolonged contraction in trachealis musc1e strip. Strong tonic contraction by P AF was attenuated
226.

The Characterization of the Increase of Membrane Conductance after Depolarization in Single Rat Adrenal Chromaffin Cells

WonilLim, SangJeongKim, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 12 95-100 (6 pages)

WonilLim, SangJeongKim, JunKim 저
...
- 3,000원
227.

토끼 단일 심근세포에서 대사억제시 Inward Rectifier(IK1)의 변화 Effect of Metabolic Inhibition on Inward Rectifier K Current in Single Rabbit Ventricular Myocytes

정유정, 호원경, 엄융의, YuJeongChung, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 15 741-748 (8 pages)

정유정, 호원경, 엄융의, YuJeongChung, Won-KyungHo, YungEEarm 저
...
- 3,000원
negative slope) which is a characteristic of IK1. Application of 0.2 mM dinitrophenol (DNP, an uncoupler of oxidative phosphorylation as a tool for chemical hypoxia) to the bathing solution with the pipette solution containing 5 mM ATP, produced a gradual increase of outward current followed by a gradual decrease of inward current with little change in the reversal potential (⁣80 mV). The increase of outward current was reversed by glibenclamide (10 ㄍM), suggesting that it is caused...
228.

Effect of pH on the ATP-sensitive K+ Channel in Aortic Smooth Muscle Cells from Rats

SeHoonKim, IlSuKim, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 11 555-563 (9 pages)

SeHoonKim, IlSuKim, HoeSukKim, ByeongHwaJeon, SeokJongChang 저
...
- 3,000원
The effects of pH on K⁢ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K⁢ currents were recorded in the conventional configuration of the voltage-clamp technique. Pinacidil (10uM) activated the whole-cell current and the pinacidil-activated current was completely inhibited by glibenclamide (10uM) , an inhibitor of ATP-sensitive K⁢ channel (KATP channel). Pinacidil-activated current was reversed at near...
229.

Role of Intracellular Taurine in Monensin-induced Na+, Ca++ Accumulation and Mechanical Dysfunction in Isolated Rat Hearts

Young-hoonKim, Jong-wanPark, Myung-sukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 9 537-546 (10 pages)

Young-hoonKim, Jong-wanPark, Myung-sukKim 저
...
- 3,000원
It has been postulated that the intracellular taurine is co-transported with Na⁢ down a concentration gradient and prevents the intracellular accumulation of sodium. It is therefore, expected that an elevated level of intracellular taurine prevents the sodium-promoted calcium influx to protect the cellular damages associated with sodium and calcium overload. In the present study, we evaluated the effects of intra- and extracellular taurine on the myocardial Na⁢ and Ca⁢⁢...
230.

Blockade of Intrinsic Oscillatory Activity of Cerebellar Purkinje Cells by Apamin and Nickel

WhasookSeo, JeanC.Strahlendorf, HowardK.Strahlendorf 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 2 477-484 (8 pages)

WhasookSeo, JeanC.Strahlendorf, HowardK.Strahlendorf 저
...
- 3,000원
blocking action on the post-burst hyperpolarization before it blocked oscillatory activity. Ni2⁢ blocked an inward current at potentials positive to approximately ⁣65 mV, which was responsible for the ZSR region and outward current at more negative potentials. These data indicated that oscillatory activity of PCs is sustained by a balance between a slow Ni2⁢-sensitive inward current and an apamin-sensitive outward current in the region of ZSR of the whole-cell I/V curve.

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