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EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITORS ON OSTEOCLAST-LIKE CELL FORMATION
Seung-Kyu Ahn, Jung-Kun Kim, Kyung-Suk Cha 대한치과교정학회 The Korean Journal of Orthodontics 8 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 7 715-722 (8 pages)
in cultures of chick embryo bone marrow. 2. Nitric oxide synthase inhibitors(NOSI ; N-NMA, N-NAME) stimulated the osteoclast-like cells in cultures of chick embry bone marrow. 3. 1,25-dihydroxyvltamine D³ and nitric oxide synthase inhibitors did not appear to have additive effect on the generation of TRAP-positive MNCs. These results suggest that nitric oxide synthase inhibitors may stimulate the osteoclast-like multinucleated cell formation and fusion in cultures of chick bone marrow. -
EFFECTS OF SEVERAL CYTOKINES ON THE FUNCTIONS OF FETAL RAT OSTEOBLAST-LIKE CELLS IN VITRO
Hee-Sung Han, Jung-Keun Kim, Young-Il Chang 대한치과교정학회 The Korean Journal of Orthodontics 8 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 4 689-696 (8 pages)
Effects of several cytokines(IL -1β, TNFα, and IFNγ) have been examined on fetal rat osteoblast-like cells. To investigate whether cytokines play direct causal roles in production of lysosomal enzyme, fetal rat osteoblast-like cells were treated with IL-1β, TNFα, and IFNγ, respectively or combined. And acid phosphatase was determined by biochemical method. Alkaline phosphatase was assayed to determine the effects of IL-1β, TNFα, and IFNγ on the... -
1,25-Dihydroxyvitamin D₃가 치주인대세포활성 및 실험적 치아이동에 미치는 영향에 관한 연구
김성우(Sung-Woo Kim), 박동권(Dong-Kwon Park), 김상철(Sang Cheol Kim) 대한치과교정학회 The Korean Journal of Orthodontics 13 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1997, 제 27권 제 2호 14 335-347 (13 pages)
교정치료시 치아이동은 치주인대세포를 매개로 골조직의 개조가 일어나는 과정으로서 골조직의 성장과 개조는 조골세포, 파골세포 및 그 전구헤포의 증식, 분화 및 활성에 영향을 미치는 여러가지 전신적 인자와 국소적 인자에 의하여 조절되고 있다. 1,25-Dihydroxyvitamin D3의 대사물로서 경조직에 있어서 칼슘과 인산의 이동에 중요한 역할을 담당하고 있는 것으로 알려져 있으나 치주인대에 대한 1,25-Dihydroxyvitamin D3의 생물학적 기능은 잘 알려져 있지 않다. 1,25-Dihydroxyvitamin D3가 치주인대세초의 활성에 미치는 영향을... -
C2C12 골격근세포에서 황기의 미토콘드리아 조절 작용
송미영(Mi Young Song) 한방비만학회 대한한방비만학회지 8 Pages
한방비만학회 대한한방비만학회지 2014, 제 14권 제 2호 2 55-62 (8 pages)
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C2C12 골격근 세포에서 백출의 분화 조절 효능
송미영(Mi Young Song) 한방비만학회 대한한방비만학회지 7 Pages
한방비만학회 대한한방비만학회지 2015, 제 15권 제 1호 5 38-44 (7 pages)
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이차구개 형태분화의 내적 조절유전자 규명
이재국, 장은하, 임양희, 김기병, 고승오, 조의식, 신효근 대한구순구개열학회 대한구순구개열학회지 16 Pages
대한구순구개열학회 대한구순구개열학회지 2007, 제 10권 1호 1 1-16 (16 pages)
Insulin-like growth factor binding protein 7(IGFbp7 ), Sui 1 homologs(Sui1 ), Defender against cell death 1(Dad1 )이었다. 검출된 유전자를 동정하여 정상생쥐의 구개 형성과정에서의 발현양상을 알아본 결과, Col2a1 을 제외한 유전자들은 모두 E13.5의 구개선반에서 특이적으로 발현되고 있었으나 구개선반이 융합된 E15.5에서는 Vim, Txnl5 그리고 Dad1 만이 봉합선을 따라 발현이 지속되고 있었다. 이상의 결과로 보아 검출된 유전자들은 구개선반의 형태분화과정에서 발현되어 이차구개의 형성과정에 관여할 것으로 여겨진다.... -
Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
Md Jamal Uddin, Eun Seon Pak, Hunjoo Ha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 10 567-575 (9 pages)
Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER... -
Antipruritic effect of curcumin on histamine-induced itching in mice
Han Kyu Lee, Seok Bum Park, Su-youne Chang, Sung Jun Jung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 8 547-554 (8 pages)
Itching is a common clinical symptom of skin disease that significantly affects a patient’s quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced... -
Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
Seon-Hui Jang, Soo-Joung Park, Chang-Jin Lee, Dong-Kuk Ahn, Seong-Kyu Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 7 539-546 (8 pages)
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action... -
Role of inflammasomes in inflammatory autoimmune rheumatic diseases
Young-SuYi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 1 1-15 (15 pages)
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)-1β and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such...


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