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241.

Development of Estimation Methods of Skin Oxidation and Evaluation of Anti-Oxidative Effects of Genistein in Topical Formulations

SeongYeonKim, YeonJooNa, DongjuKim, YeongseokKim, HyeongMinKim, Sung-HaHwang, JiyeonKwak, Hyo-JeongKuh, JaehwiLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 9 205-209 (5 pages)

SeongYeonKim, YeonJooNa, DongjuKim, YeongseokKim, HyeongMinKim, Sung-HaHwang, JiyeonKwak, Hyo-JeongKuh, JaehwiLee 저
...
- 1,500원
The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion (Fe3＋) and xylenol orange, often called FOX assay and subsequent monitoring of...
242.

Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines

InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 2 159-165 (7 pages)

InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 저
...
- 3,000원
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion....
243.

Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca2＋-activated K＋ Channels

YangmiKim, Wun-JaeKim, , Eun-JongCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 5 279-284 (6 pages)

YangmiKim, Wun-JaeKim, , Eun-JongCha 저
...
- 3,000원
Quercetin (3,3',4',5,7-pentahydroxyflavone) is an attractive therapeutic flavonoid for cancer treatment because of its beneficial properties including apoptotic, antioxidant, and antiproliferative effects on cancer cells. However, the exact mechanism of action of quercetin on ion channel modulation is poorly understood in bladder cancer 253J cells. In this study, we demonstrated that large conductance Ca2＋- activated K＋ (BKCa) or MaxiK channels were functionally expressed in 253J cells, and...
244.

Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells

JiyoungKim, Jae-WonLee, Song-InKim, Yong-JoonChoi, Won-KiLee, Myung-JaJeong, Sang-HoonCha, HeeJaeLee, WanjooChun, Sung-SooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 4 211-216 (6 pages)

JiyoungKim, Jae-WonLee, Song-InKim, Yong-JoonChoi, Won-KiLee, Myung-JaJeong, Sang-HoonCha, HeeJaeLee, WanjooChun, Sung-SooKim 저
...
- 3,000원
Glioblastoma multiforme is one of the most common and aggressive tumors in central nervous system. It often possesses characteristic necrotic lesions with hemorrhages, which increase the chances of exposure to thrombin. Thrombin has been known as a regulator of MMP-9 expression and cancer cell migration. However, the effects of thrombin on glioma cells have not been clearly understood. In the present study, influences of thrombin on glioma cell migration were examined using Boyden chamber...
245.

Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells

YongJinKim, EunAeKim, UyDongSohn, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 14 441-447 (7 pages)

YongJinKim, EunAeKim, UyDongSohn, ChulBuYim, ChaeukIm 저
...
- 3,000원
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities against human renal cancer Caki-2 and leukemic cancer HL-60 in the MTT assay. Some compounds (12, 15, and 16) showed stronger cytotoxicity than B13 and C6-ceramide against both tumor cell lines, and compound (12) gave the most potent activity with IC50 values of 36 and 9</SUB>ՌM,...
246.

Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells

ChiHyunKim, Yeong-MinYoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 3 365-369 (5 pages)

ChiHyunKim, Yeong-MinYoo 저
...
- 1,500원
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and time-dependent manner. Melatonin treatment (0 to 3 mM) induced the fragmentation of poly(ADP- ribose) polymerase (PARP) and activation of caspase-3, caspase-8, and caspase-9. Moreover, melatonin markedly activated Bax expression and decreased Bcl-2 expression in dose increments. To investigate p53 and p21...
247.

CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells

Kyoung-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 13 331-336 (6 pages)

Kyoung-HwaLee 저
...
- 3,000원
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 con</SUB>sumption and supply. Hypoxia Inducible Factor (HIF)-1Ձ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-1Ձ-targeting...
248.

Identification of Differentially Expressed Genes in Bovine Follicular Cystic Ovaries

ChangyongChoe, Young-WooCho, Chang-WoonKim, Dong-SooSon, JaeheeHan, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 3 265-272 (8 pages)

ChangyongChoe, Young-WooCho, Chang-WoonKim, Dong-SooSon, JaeheeHan, DawonKang 저
...
- 3,000원
Follicular cystic ovary (FCO) is one of the most frequently diagnosed ovarian diseases and is a major cause of reproductive failure in mammalian species. However, the mechanism by which FCO is induced remains unclear. Genetic alterations which affect the functioning of many kinds of cells and/or tissues could be present in cystic ovaries. In this study, we performed a comparison analysis of gene expression in order to identify new molecules useful in discrimination of bovine FCO with follicular...
249.

Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

HiroyasuSatoh, SetsukoTohno, TakeshiMinami, TakaoOishi, MotoharuHayashi, YoshiyukiTohno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 1 249-256 (8 pages)

HiroyasuSatoh, SetsukoTohno, TakeshiMinami, TakaoOishi, MotoharuHayashi, YoshiyukiTohno 저
...
- 3,000원
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were...
250.

Activation of PPARα Attenuates IFNγ and IL-1β-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway

Jin-KooLee, Eun-MinSeo, Sang-SooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Seon-MiKim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 11 185-189 (5 pages)

Jin-KooLee, Eun-MinSeo, Sang-SooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Seon-MiKim, Hong-WonSuh 저
...
- 1,500원
The present study demonstrates the effect of fibrates, agonists of PPARՁ on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1Ղ (10 ng/ml), IFNՃ (10 ng/ml), and TNF-Ձ (10 ng/ml) cause a significant increase of cell proliferation in a time-dependent manner. Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 ՌM) reduced the IFNՃ and IL-1Ղ-induced cell proliferation...

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