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Overexpressed Mitochondrial Thioredoxin Protects PC12 Cells from Hydrogen Peroxide and Serum-deprivation
Yun-SongLee, Seung-AYu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 7 33-37 (5 pages)
Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective roles in organisms under oxidative stress through redox reaction by using reducing equivalents of cysteines at a conserved active site, Cys-X-X-Cys. Whereas biological and physiological properties of Trx1 are well characterized, significance of mitochondrial thioredoxin (Trx2) is not well known.... -
Molecular Aspects of Organic Ion Transporters in the Kidney
SeokHoChaHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 1 107-122 (16 pages)
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the body from harmful substances. The renal proximal tubule is the primary site of carrier-mediated transport from blood into urine. During the last decade, molecular cloning has identified several families of multispecific organic anion and cation transporters, such as organic anion transporter... -
Effect of Atrial Natriuretic Peptide on the Proliferation and Activity of Osteoblastic Cells
Jong-RyeulLee, Seon-YleKo, Jung-KeunKim, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 3 283-289 (7 pages)
Natriuretic peptides comprise a family of three structurally related peptides; atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The present study was performed to investigate the effect of ANP on the proliferation and activity of ROS17/2.8 and HOS cells which are well-characterized osteoblastic cell lines. ANP dose-dependently decreased the number of ROS17/2.8 and HOS cells after 48-hour treatment. ANP generally increased the alkaline... -
Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats
EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of rats. Channel activity was recorded from membrane patches using the patch-clamp technique. In the inside-out configuration bath-applied propofol inhibited the KATP channel activities in a dose-dependent manner. The half-maximal inhibition dose (ED50) was 48.6⁑8.4μM... -
Effects of Bradykinin on Intracellular Calcium Transients in Cardiac Myocytes
Choon-OkPark, YangMiKim, JaeHeeHan, DavidG.Allen, SeongGeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 10 615-621 (7 pages)
ionic currents using whole cell voltage clamp technique in rabbit cardiomyocytes and on the intracellular Ca2 transient using calcium sensitive fluorescence dye, indo-1AM. Simultaneously with recording intracellular Ca2 transients, cell contractility was estimated from the changes in length of the electrical stimulated rat cardiac myocytes. L-type Ca2 current decreased by bradykinin at the entire voltage range. Inward tail current increased initially up to its maximum about... -
Effect of Ethanol on Na+-Pi Uptake in Opossum Kidney Cells Role of Membrane Fluidization and Reactive Oxygen Species
InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 10 529-538 (10 pages)
This study was undertaken to examine the effect of ethanol on Na-dependent phosphate (Na-Pi) uptake in opossum kidney (OK) cells, an established renal proximal tubular cell line. Ethanol inhibited Na-dependent component of phosphate uptake in a dose-dependent manner with I50 of 8.4%, but it did not affect Na-independent component. Similarly, ethanol inhibited Na-dependent uptakes of glucose and amino acids (AIB, glycine, alanine, and leucine). Microsomal... -
Study on the Action by PAF on IL-1 Modulation in Alveolar Macrophages Involvement of Endogenous Arachidonate Metabolites and Intracellular Ca++ Mobilization
JiheeLee, Won-KiKim, Jong-SikHah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 13 241-249 (9 pages)
in alveolar macrophages were evaluated using the calcium-sensitive dye fura-2 at the single cell level. PAF at any dose between 10-16 and 10-8 M did not increase intracellular calcium. Furthermore, there was no effective change of intracellular calcium level when PAF was added to alveolar macrophages in the presence of LPS or LPSLTB4, and 4, 24 and 48h after treatment of these stimulants. Together, the results indicate that IL-1 activity induced by PAF is differently regulated through... -
이자효소 분비에 관여하는 세포 내 조절 단백에 대한 연구
정구용(Ku Yong Chung), 최재원(Jae Won Choi), 최홍순(Hong Soon Choi), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 2호 12 243-258 (16 pages)
