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Effects of α1-Adrenergic Receptor Stimulation on Intracellular Na+ Activity and Twitch Force in Guinea-Pig Ventricular Muscles
Chae, Soo-Wan, Gong, Q.Y., Wang, D.Y., Lee, Chin-O. 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 2 203-216 (14 pages)
The effects of α1-adrenergic receptor stimulation on membrane potential, intracellular Na+ activity, and twitch force were investigated in ventricular muscles from guinea-pig hearts. Action potentials, intracellular Na+ activity, and twitch force of ventricular papillary muscles were measured simultaneously under various experimental conditions. Stimulation of the α1-adrenergic receptor by phenylephrine produced variable changes in action potential duration, a slight hyperpolarization of the... -
Effects of High Glucose on Na,K-ATPase and Na/glucose Cotransporter Activity in Primary Rabbit Kidney Proximal Tubule Cells
Han, Ho-Jae 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 7 69-80 (12 pages)
be central components in the progression to renal failure, an understanding of their underlying causes is potentially important for the development of therapy. A primary rabbit kidney proximal tubule cell culture system was utilized to evaluate the possibility that the renal proximal tubular hypertrophy and hyperfunction observed in vivo in diabetes mellitus, can be attributed to effects of elevated glucose levels on membrane transport systems. Primary cultures of rabbit proximal tubules, which... -
The Action of Ginkgo Bibloba Extract in the Isolated Rabbit Corpus Cavernosum
Chung, Woo-Sik, Choi, Young-Deuk, Park, Young-Yo, Hah, Jong-Sik 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 6 61-68 (8 pages)
The extract of Ginkgo bibloba (EGb) is a complex mixture of natural products from the Ginkgo leaves and clinically used for the treatment of cerebral and peripheral circulatory disturbances due to its combined activity of several vasoactive principles. In this study we investigated the action of EGb and its mechanism in isolated rabbit corporal smooth muscle to evaluate the possibility of using this material as a pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ... -
Transformation of Rabbit Proximal Tubule Cells by Strontium Phosphate Transfection with a Plasmid Containing SV4O Early Region Genes
Han, Ho-Jae, Taub, Mary L., 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 14 233-240 (8 pages)
In this study, it was investigated whether immortalized proximal tubule cells transformed with pRSVT could survive through the numerous passages. Results were as follows: 1. The cells transfected with pRSVT formed rapidly growing, multilayered colonies within 2 weeks in a hormone defined medium. Domes were also observed in some of the cultures. 2. r-glutamyl transpeptidase activity was equivalent to that observed in primary renal proximal tubule cell cultures. 3. Transformed cells with pRSVT... -
Ca2+-activated Cl- Current in Gastric Antral Myocytes
Lee, Moo-Yeol, Bang, Hyo-Weon, Uhm, Dae-Yong, Rhee, Sang-Don 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 4 143-150 (8 pages)
The whole-cell mode of the patch clamp technique was used to study Ca2+-activated Cl- current (IClCa) in gastric antral myocytes. Extracellular application of caffeine evoked Ca2+-activated current. In order to isolate the chloride current from background current, all known systems were blocked with specific blockers. The current-voltage relationship of caffeine-induced current showed outward rectification and it reversed at around ECl-. The shift of reversal potential upon the alteration of... -
Conduction Block of the Primary Afferent Fibers by Topically Applied Allyl Isotheocyanate
Shin, Hong-Kee, Kim, Kee-Soon, 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 2 123-132 (10 pages)
The present study was undertaken to elucidate the desensitization of cutaneous receptors and the conduction block of the afferent nerves induced by direct application of allyl isotheocyanate (mustard oil) to the receptive field (RF) or onto the afferent nerve, respectively. Dorsal horn cell responses to mechanical stimulations of RF were completely suppressed when mustard oil was applied to either the afferent nerve or the whole area of RF. C-fiber responses of dorsal horn cells were more... -
Electrophysiological Study on Medullospinal Tract Cells Related to Somatosympathetic Reflex in the Cat
Kim, Sang-Jeong, Goo, Yong-Sook, Kim, Jun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 8 75-88 (14 pages)
It is well established that neurons in ventrolateral medulla play a key role in determining the vasomotor tone. The purpose of present study is to identify sympathetic related, medullospinal tract neurons in ventrolateral medulla and to show that these mediate somato-sympathetic reflex. Medullospinal tract cells were identified by antidromic stimulation to intermediolateral nucleus (IML) of the second thoracic (T2) spinal cord in anesthetized cats. Peripheral nerves were stimulated for... -
Cl--sensitive Component of Ca2+-activated Tail Current in Rabbit Atrial Myocytes
Park, Choon-Ok, So, In-Suk, Ho, Won-Kyung, Kim, Woo-Gyeum, Earm, Yung-E 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 3 27-36 (10 pages)
We used the whole cell patch clamp technique to examine the ionic basis for the tail current after depolarizing pulse in single atrial myocytes of the rabbit. We recorded the tail currents during various repolarizations after short depolarizing pulse from a holding potential of -70 mV. The potassium currents were blocked by external 4-aminopyridine and replacement of internal potassium with cesium. The current was reversed to the outward direction above +10 mV. High concentrations of... -
Role of Rostroventrolateral Medulla in Somatosympathetic Pressor and Depressor Response Evoked by Peripheral Nerve Stimulation
Jun, Jae-Yeoul, Yeum, Cheol-Ho, Goo, Yong-Sook, Kim, Jun 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 2호 10 201-210 (10 pages)
The rostral ventrolateral medulla (RVLM) has been established recently as a sympathoexcitatory area. The present study was conducted to investigate whether the somatosympathetic pressor and/or depressor responses are mediated through RVLM in cats anesthetized with α-chloralose. An occipital craniectomy was performed and ventrolateral medulla were stimulated either electrically or chemically to evoke changes in arterial blood pressure. And then the effect of lesions in the ventrolateral medulla... -
Central Projections of Sensory Information Produced by Topical Application of Capsaicin to the Tongue in the Cat
Hong, Seung-Kil, Nahm, Sook-Hyun, Han, Hee-Chul, Suh, Young-Suk, Won, Ran, Lee, Bae-Hwan 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 9 87-100 (14 pages)
In order to elucidate whether capsaicin applied topically acts as a pain-producing subastance or as a tastant, neuronal activities of the chorda tympani nerve(CN), lingual nerve(LN), solitary tract nucleus(STN), and trigeminal nucleus(TGN) were recorded while thermal and taste stimuli, and capsaicin were being applied topically, and algesics intra-arterially to the tongue of cats anesthetized with α-chloralsoe. In addition, the STN neurons were examined after wheat germ agglutinin-horseradish...


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