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361.

Mouse Leukemia 세포에서 Adenosine 5’-triphosphate에 의 한 Apoptosis

주난영, 박규상, 정해숙, 공인덕, 이중우 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 23 817-824 (8 pages)

주난영, 박규상, 정해숙, 공인덕, 이중우 저
...
- 3,000원
Apoptosis Induced by Adenosine 5’-triphosphate in Mouse Leukemic Cells. Nan Young Joo， Kyu Sang Park， Hae Sook Chung， In Deok Kong， and Joong Woo Lee Department of Physio1ogy， Yonsei University W onju College of Medicine， W onju 220 - 701， Korea Extracell띠ar ATP elicits various biological responses and plays a significant role in physiological regulation. Recent1y， ATP-induced growth inhibitions were reported in some tumor cell lines， but these effects and mechanisms are not well...
362.

타액분비 및 선혈류 조절에 대한 내인성 산화질소의 역할

김원재, 남상채, 김미원 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 22 809-816 (8 pages)

김원재, 남상채, 김미원 저
...
- 3,000원
Role of Endogenous Nitric Oxide in the Control of Salivary Secretion and Blood Flow. W onjae Kim， Sang Chae Nam\ and Miwon Kim1 Department of Oral Physiology & Institute of Dental Research， Chonnam National University Dental School and lDepartment of Physiology， Chonnam National Medical School， Kwan밍u501-190， Korea The present study was designed to investigate whether endogenous niπic oxide(EDNO) is involved in submandibular vasodilation and salivation induced by parasympathetic nerve...
363.

Endothelin Increases Intracellular Free Calcium in Isolated Rat Nephron

SeokHoCha, Young-JinCho, Kweon-HaengLee, HitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 12 565-572 (8 pages)

SeokHoCha, Young-JinCho, Kweon-HaengLee, HitoshiEndou 저
...
- 3,000원
In the freshly isolated rat nephron, the effect of endothelin-1, -2 and -3 (ET-1, -2 and -3) on cytosolic free calcium concentration ([Ca2⁢]i) was determined using the fluorescent indicator Fura-2/AM. [Ca2⁢]i increase was investigated in 9 parts of the single nephron including glomerulus (Glm), S1, S2, S3, cortical and medullary thick ascending limb and cortical (CCT) and outer medullary collecting tubule (OMCT). Endothelins increased [Ca2⁢]i in Glm (ET-1; 127±17%, ET-2;...
364.

Role of Tyrosine Kinases in Vascular Contraction in Deoxycorticosterone Acetate-Salt Hypertensive Rats

CheolHoYeum, JaeYeoulJun, HyoSubChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 10 547-553 (7 pages)

CheolHoYeum, JaeYeoulJun, HyoSubChoi 저
...
- 3,000원
It has been known that activation of tyrosine kinases is involved in signal transduction. Role of the tyrosine kinase in vascular smooth muscle contraction was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male Sprague-Dawley rats underwent uninephrectomy, one week after which they were subcutaneously implanted with DOCA (200 mg/kg) and supplied with 1% NaCl and 0.2% KCl drinking water for 4∼6 weeks. Control rats were treated the same except for that no DOCA was...
365.

Altered Vascular Calcium Regulation in Hypertension

Won-jaeKim, Jong-unLee, YongHyunPark, SangChaeNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 8 529-535 (7 pages)

Won-jaeKim, Jong-unLee, YongHyunPark, SangChaeNam 저
...
- 3,000원
of the endothelium-denuded aortic preparations were determined. Caffeine (0.1∼35 mmol/L) induced a greater contraction in 2K1C and DOCA-salt hypertension than in normotensive control. When the vascular calcium store was functionally-depleted by a repeated exposure to caffeine, it took longer to reload the store and to resume the initial contraction force in response to caffeine in both 2K1C and DOCA-salt hypertension. The vascular 45Ca uptake following the functional depletion of the cellular...
366.

Nitric Oxide Prevents the Bovine Cerebral Endothelial Cell Death Induced by Serum-Deprivation

ChulHoonKimYoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 6 515-521 (7 pages)

ChulHoonKimYoungSooAhn 저
...
- 3,000원
Endothelial cells play a central role in the inflammatory processes, and activation of nuclear factor kappa B (NF-κB) is a key component in that inflammatory processes. Previously, we reported that tumor necrosis factor alpha(TNFα) had protective effect of cell death induced by serum deprivation and this protection was related to NF-κB activation. Inducible nitric oxide synthase (iNOS) is a member of the molecules which transcription is regulated mainly by NF-κB. And the role of nitric...
367.

Mechanisms Underlying Relaxations Caused by Angiotensin II and Its Analogs in Isolated Rabbit Mesenteric Artery

KiWhanHong, , JiYoungPark, ChiDaeKim, WonSukLee, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 6 393-402 (10 pages)

KiWhanHong, , JiYoungPark, ChiDaeKim, WonSukLee, ByungYongRhim 저
...
- 3,000원
in the aortic segment with endothelium. 2) AII-induced endothelium-dependent relaxation was markedly inhibited by Nw-nitro- L-arginine (L-NNA, 100 ㄍM), methylene blue (10 ㄍM) and LY83583 (10 ㄍM), respectively. 3) Inhibition of cyclooxygenase with indomethacin (10 ㄍM) strongly decreased the vasorelaxant response to AII irrespective of the presence of endothelium. 4) 7-Ethoxyresorufin (1 ㄍM) and clotrimazole (1 ㄍM), inhibitors of cytochrome P-450-dependent...
368.

Distributional Patterns of Phospholipase C Isozymes in Heart and Brain of Spontaneously Hypertensive and Normotensive Rats

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 5 385-392 (8 pages)

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 저
...
- 3,000원
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in the genetic hypertensive rats. As the first step of knowing the role of PLC on hypertension, we investigated the distribution of 6 PLC isozymes (PLC-β1, -β3, -β4, -γ1, -γ2 and -δ1) in the heart and brain, which are concerned with...
369.

Regulatory Role of Nitric Oxide on Atrial Natriuretic Peptide System in Normotensive and Hypertensive Rats

Eun-HahChoi, MiwonKim, Jong-UnLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 10 79-82 (4 pages)

Eun-HahChoi, MiwonKim, Jong-UnLee 저
...
- 1,500원
The present study was aimed to explore an interaction between endothelium-derived nitric oxide (NO) and atrial natriuretic peptide (ANP) systems in normotensive and hypertensive states. Rats were made two-kidney, one clip (2K1C) hypertensive and supplemented with either NG-nitro-L-arginine methyl ester (L-NAME, 5 mg/100 ml drinking water) or L-arginine hydrochloride (400 mg/100 ml drinking water). One group supplied with normal tap water served as control. Sham-clipped rats were also divided...
370.

PC12 세포에서 Sertraline을 위시한 항우울제에 의한 칼슘길항 유사효과

박기창, 공인덕, 정해숙, 박규상, 한준규, 이중우, 백인호 대한신경정신의학회 신경정신의학 14 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 14 548-561 (14 pages)

박기창, 공인덕, 정해숙, 박규상, 한준규, 이중우, 백인호 저
...
- 4,300원
본 실험에서는 PC12 세포를 신경세포 모델로 형광물질인 fura-2 및 bisoxonol을 이용하여 세포내 유리 칼슘이온 농도 및 막전압을 각각 측정하여 화학구조가 서로 다른 몇몇 항우울제가 막전압 의존성 칼슘통로 의 활성화 및 ATP를 통한 수용체 의존성 칼슘통로의 활성화에 미치는 영향을 관찰하여 아래와 같은 결과를 얻었다. 1) 선택적 serotonin 재흡수 억제제의 하나인 sertraline은 60mM KCl 자극 및 100μM ATP 자극에 의 한 [Ca2＋]i 의 증가를 억제하였으며 이때 IC 50 값은 각각 2.5μM과 5.3μM이었다. 2) 막전압 의존성...

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