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451.

Effect of Imipramine on Calcium Utilization of Single Cells Isolated from Canine Detrusor

Ho-ShikShim, Hyoung-ChulChoi, Young-SookJeong, Jong-HoKim, Kwang-YounLee, Uy-DongSohn, Jeoung-HeeHa, Won-JoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 9 439-445 (7 pages)

Ho-ShikShim, Hyoung-ChulChoi, Young-SookJeong, Jong-HoKim, Kwang-YounLee, Uy-DongSohn, Jeoung-HeeHa, Won-JoonKim 저
...
- 3,000원
This study is to investigate the mechanism of inhibitory effect of imipramine on the calcium utilization in single cells isolated from canine detrusor. 2 mm thick smooth muscle chops were incubated in 0.12% collagenase solution at 36oC, and aerated with 95% O2/5% CO2, and then cell suspension was examined. Acetylcholine (ACh) evoked a concentration-dependent contraction of the isolated detrusor cells in normal physiologic salt solution (PSS), and the ACh-induced contraction was significantly...
452.

Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes

Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)

Yong-GeunKwakSoo-WanChae 저
...
- 4,000원
phosphatase 2A (PP2A, 1 U ml⁣1). In addition, pinacidil (10 μM) could not induce the opening of the reactivated KATP channels in the presence of H-7 (100 μM) but enhanced it in the presence of ATP (1 mM) and genistein (30 μM). These results indicate that the KATP channel-opening effect of pinacidil is not mediated via phosphorylation of KATP channel protein or associated protein, although it still requires the phosphorylation of serine/threonine residues as a prerequisite condition.
453.

Evidence for Adenosine Triphosphate (ATP) as an Excitatory Neurotransmitter in Guinea-Pig Gastric Antrum

TongMookKang, WenxieXu, SungJoonKim, SeungCheolAhn, YoungChulKim, InsukSo, MyoungKyuPark, Dae-YongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 6 165-174 (10 pages)

TongMookKang, WenxieXu, SungJoonKim, SeungCheolAhn, YoungChulKim, InsukSo, MyoungKyuPark, Dae-YongUhm, KiWhanKim 저
...
- 3,000원
We explore the question of whether adenosine 5'-triphosphate (ATP) acts as an excitatory neurotransmitter in guinea-pig gastric smooth muscle. In an organ bath system, isometric force of the circular smooth muscle of guinea-pig gastric antrum was measured in the presence of atropine and guanethidine. Under electrical field stimulation (EFS) at high frequencies (＞20 Hz), NO-mediated relaxation during EFS was followed by a strong contraction after the cessation of EFS (a...
454.

Effects of Dexamethasone and DHEA on the Responses of Rat Cerebral Cortical Astrocytes to Lipopolysaccharide and Antimycin A

Sang-HyunChoi, Hyung-GunKim, Chang-KeunKim, Nan-HyangPark, Dong-HeeChoi, In-SopShim, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 2 127-135 (9 pages)

Sang-HyunChoi, Hyung-GunKim, Chang-KeunKim, Nan-HyangPark, Dong-HeeChoi, In-SopShim, Boe-GwunChun 저
...
- 3,000원
As part of a study on the effects of dexamethasone and dehydroepiandrosterone (DHEA) on the biological roles of astrocytes in brain injury, this study evaluated the effects of dexamethasone and DHEA on the responses of primary cultured rat cortical astrocytes to lipopolysaccharide (LPS) and antimycin A. Dexamethasone decreased spontaneous release of LDH from astrocytes, and the dexamethasone effect was inhibited by DHEA. However, the inhibitory effect of DHEA on the dexamethasone-induced...
455.

The Roles of Arachidonic Acid and Calcium in the Angiotensin II-induced Inhibition of Na+ Uptake in Renal Proximal Tubule Cells

SooHyunPark, HyunJooKoh, YeunHeeLee, ChangHoSon, MinKyoungPark, YoungJaeLee, HoJaeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 11 83-91 (9 pages)

SooHyunPark, HyunJooKoh, YeunHeeLee, ChangHoSon, MinKyoungPark, YoungJaeLee, HoJaeHan 저
...
- 3,000원
Angiotensin II (ANG II) has a biphasic effect on Na⁢ transport in proximal tubule: low doses of ANG II increase the Na⁢ transport, whereas high doses of ANG II inhibit it. However, the mechanisms of high dose ANG II-induced inhibition on Na⁢ uptake are poorly understood. Thus the aim of the present study was to investigate signal transduction pathways involved in the ANG II-induced inhibition of Na⁢ uptake in the primary cultured rabbit renal proximal tubule cells (PTCs)...
456.

Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes

JinShangKimAntonioScarpa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 8 59-68 (10 pages)

JinShangKimAntonioScarpa 저
...
- 3,000원
occurred when Na⁢-free buffer was switched to 120 mM Na⁢ containing buffer. A similar Mg2⁢ efflux was observed in myocytes. These effluxes were inhibited by quinidine and imipramine. These results indicate that the activation of Mg2⁢ effluxes by hormonal stimulation is directly dependent on intracellular Mg2⁢ contents and that these Mg2⁢ effluxes appear to occur through the Na⁢-dependent Na⁢/Mg2⁢ exchange system during chemical hypoxia.
457.

Calcium Modulates Excitatory Amino Acid (EAA)- and Substance P-induced Rat Dorsal Horn Cell Responses

HongKeeShin, SokHanKang, InDukChung, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 5 35-45 (11 pages)

HongKeeShin, SokHanKang, InDukChung, KeeSoonKim 저
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- 4,000원
Excitatory amino acid (EAA) and substance P (SP) have been known to be primary candidates for nociceptive neurotransmitter in the spinal cord, and calcium ions are implicated in processing of the sensory informations mediated by EAA and SP in the spinal cord. In this study, we examined how Ca2⁢ modified the responses of dorsal horn neurons to single or combined iontophoretical application of EAA and SP in the rat. All the LT cells tested responded to kainate, whereas about 55% of low...
458.

The Mechanism of t-Butylhydroperoxide-Induced Apoptosis in IMR- 32 Human Neuroblastoma Cells

Jung-AeKim, YongSooLee, KeunHuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 3 19-28 (10 pages)

Jung-AeKim, YongSooLee, KeunHuh 저
...
- 3,000원
by EGTA, an extracellular Ca2⁢ chelator or by flufenamic acid (FA), a non-selective cation channel (NSCC) blocker. These results indicate that the TBHP-induced intracellular Ca2⁢ increase may be due to Ca2⁢ influx through the activation of NSCCs. In addition, treatment with either an intracellular Ca2⁢ chelator (BAPTA/AM) or FA significantly suppressed the TBHP-induced apoptosis. Moreover, TBHP increased the expression of p53 gene but decreased c-myc gene expression....
459.

Mechanism of Membrane Hyperpolarization by Extracellular K+ in Resistance-sized Cerebral Arterial Muscle Cell of Rabbit

SeHoonKim, KunMooChoi, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 1 1-10 (10 pages)

SeHoonKim, KunMooChoi, HoeSukKim, ByeongHwaJeon, SeokJongChang 저
...
- 3,000원
We sought to find out the mechanism of vascular relaxation by extracellular K⁢ concentration ([K⁢]o) in the cerebral resistant arteriole from rabbit. Single cells were isolated from the cerebral resistant arteriole, and using voltage-clamp technique barium-sensitive K⁢ currents were recorded, and their characteristics were observed. Afterwards, the changes in membrane potential and currents through the membrane caused by the change in [K⁢]o was observed. In the smooth...
460.

Increase of L-type Calcium Current by cGMP-dependent Protein Kinase Regulates in Rabbit Ventricular Myocytes

JinHan, NariKim, EuiyongKim, WonkyungHo, YungEEarm, HankyounKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 10 733-742 (10 pages)

JinHan, NariKim, EuiyongKim, WonkyungHo, YungEEarm, HankyounKim 저
...
- 3,000원
different species, suggesting that the activation of cGMP-PK is involved in the facilitation of ICa by cGMP. However, there is no direct evidence that cGMP-PK can stimulate ICa in rabbit ventricular myocytes. In this report, we focused on the direct effect of cGMP-PK on ICa in rabbit ventricular myocytes. Methods and Results: We isolated single ventricular myocytes of rabbit hearts by using enzymatic dissociation. Regulation of ICa by cGMP-PK was investigated in rabbit ventricular myocytes using...

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