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481.

Regulation of the Contraction Induced by Emptying of Intracellular Ca2+ Stores in Cat Gastric Smooth Muscle

Hye-JungBaek, Sang-SooSim, Duck-JooRhie, ShinHeeYoon, SangJuneHahn, Yang-HyeokJo, Myung-SukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 5 113-120 (8 pages)

Hye-JungBaek, Sang-SooSim, Duck-JooRhie, ShinHeeYoon, SangJuneHahn, Yang-HyeokJo, Myung-SukKim 저
...
- 3,000원
To investigate the mechanism of smooth muscle contraction induced by emptying of intracellular Ca2⁢ stores, we measured isometric contraction and 45Ca2⁢ influx. CaCl2 increased Ca2⁢ store emptying- induced contraction in dose-dependent manner, but phospholipase C activity was not affected by the Ca2⁢ store emptying-induced contraction. The contraction was inhibited by voltage-dependent Ca2⁢ channel antagonists dose dependently, but not by TMB-8 (intracellular...
482.

Differential Effects of Nitric Oxide Synthase Inhibitors in Rats

Jun-HeeLee, ChangYellShin, BongSuKang, JiHoonJeong, KyeongBumChoi, YoungSilMin, JinHakKim, InHoiHuh, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 3 99-104 (6 pages)

Jun-HeeLee, ChangYellShin, BongSuKang, JiHoonJeong, KyeongBumChoi, YoungSilMin, JinHakKim, InHoiHuh, UyDongSohn 저
...
- 3,000원
We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, NG-monomethyl-L-arginine (L-NMMA, 3μM) or NG-nitro-L-arginine methylester (L-NAME, 30μM), augmented phenylephrine (PE, 10⁣7 M)-induced contraction which was inhibited by acetylcholine (ACh) in rat thoracic aorta. This augmentation by L-NAME or L-NMMA was attenuated with the treatment of NO precursor, arginine. ACh, however, decreased the augmentation induced by L-NMMA, but not by...
483.

Responses of Dorsal Horn Neurons to Peripheral Chemical Stimulation in the Spinal Cord of Anesthetized Cats

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 3 15-24 (10 pages)

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 저
...
- 3,000원
Although nociceptive informations are thought to be processed via different neural mechanisms depending on the types of stimuli, sufficient data have not been accumulated yet. We performed a series of experiments to elucidate the possible neural mechanisms as to chemical stimuli such as formalin, capsaicin and ATP. Single unit activity of wide dynamic range (WDR) neurons and high threshold cells were recorded extracellularly from the lumbosacral enlargement of cat spinal cord before and after...
484.

Effect of C1 Esterase Inhibitor on the Cardiac Dysfunction Following Ischemia and Reperfusion in the Isolated Perfused Rat Heart

Geon-YoungLee, Yong-KyooShin, Yoon-YoungJang, Jin-HoSong, Dae-JoongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 6 579-586 (8 pages)

Geon-YoungLee, Yong-KyooShin, Yoon-YoungJang, Jin-HoSong, Dae-JoongKim 저
...
- 3,000원
Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement- dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg)...
485.

Two Dinucleotide Repeat Polymorphisms (AC/TG and GT/CA) in the 5' Upstream Region of the Mouse Tryptophan Hydroxylase Gene

Sung-VinYim, Sung-GilChi, Sung-HyunChung, Hee-JaeLee, Mi-JaKim, Seung-JoonPark, Jee-ChangJung, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 6 501-505 (5 pages)

Sung-VinYim, Sung-GilChi, Sung-HyunChung, Hee-JaeLee, Mi-JaKim, Seung-JoonPark, Jee-ChangJung, Joo-HoChung 저
...
- 1,500원
Tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, is primarily expressed in serotonergic neurons of the raphe nuclei. Simple tandem repeat polymorphisms, typically one to four nucleotides long, are tandemly repeated several times and often characterized by many alleles. To identify the presence of polymorphic repeats, we sequenced the 5'-upstream region of the mouse TPH gene. For the detection of any allelic variants, polymerase chain reaction, nonisotopic...
486.

The Role of Somatostatin in Nociceptive Processing of the Spinal Cord in Anesthetized Cats

SungJunJung, JooMinPark, JunHoLee, JihyeLee, SangJeongKim, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 1 365-373 (9 pages)

SungJunJung, JooMinPark, JunHoLee, JihyeLee, SangJeongKim, JunKim 저
...
- 3,000원
Somatostatin (SOM) is one of the major neuropeptides in dorsal root ganglion cells, but its role in spinal nociceptive process has not been well known. In present study we aimed to investigate the effect of SOM on the response of dorsal horn neurons to the various types of peripheral nociceptive stimuli in anesthetized cats. Using carbon-filament microelectrode, the single cell activities of wide dynamic range neurons were recorded from the lumbosacral enlargement after noxious mechanical...
487.

Selective Cytotoxicity of a Novel Platinum (II) Coordination Complex on Human Gastric Cancer Cell Lines and Normal Kidney Cells

Jee-ChangJung, Young-KyuKim, Sung-VinYim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 6 283-291 (9 pages)

Jee-ChangJung, Young-KyuKim, Sung-VinYim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Young-SooRho 저
...
- 3,000원
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)]·2NO3 (PC) was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the...
488.

Involvement of Spontaneously Formed Cyclic Nucleotides in Cat Gastric Muscle Relaxation

Sang-SooSim, Hye-JungBaek, Duck-JooRhie, Shin-HeeYoon, SangJuneHahn, Yang-HyeokJo, Myung-SukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 5 275-282 (8 pages)

Sang-SooSim, Hye-JungBaek, Duck-JooRhie, Shin-HeeYoon, SangJuneHahn, Yang-HyeokJo, Myung-SukKim 저
...
- 3,000원
Muscle strips and muscle cells from cat stomach were used to investigate whether spontaneously formed cyclic nucleotides were involved in the inhibition of gastric smooth muscle contraction. A phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), increased the levels of both cyclic GMP (cGMP) and cyclic AMP (cAMP) in resting state cells, while decreasing acetylcholine-induced muscle contraction. Under the influence of IBMX, SQ22536, an adenylyl cyclase inhibitor and methylene blue, a...
489.

Effects of Dexamethasone and DHEA on the Responses of Rat Cerebral Cortical Astrocytes to Lipopolysaccharide and Antimycin A

Sang-HyunChoi, Hyung-GunKim, Chang-KeunKim, Nan-HyangPark, Dong-HeeChoi, In-SopShim, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 2 127-135 (9 pages)

Sang-HyunChoi, Hyung-GunKim, Chang-KeunKim, Nan-HyangPark, Dong-HeeChoi, In-SopShim, Boe-GwunChun 저
...
- 3,000원
As part of a study on the effects of dexamethasone and dehydroepiandrosterone (DHEA) on the biological roles of astrocytes in brain injury, this study evaluated the effects of dexamethasone and DHEA on the responses of primary cultured rat cortical astrocytes to lipopolysaccharide (LPS) and antimycin A. Dexamethasone decreased spontaneous release of LDH from astrocytes, and the dexamethasone effect was inhibited by DHEA. However, the inhibitory effect of DHEA on the dexamethasone-induced...
490.

Activation of SAPK and Increase in Bak Levels during Ceramide and Indomethacin-Induced Apoptosis in HT29 Cells

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 10 75-82 (8 pages)

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 저
...
- 3,000원
It has been reported that activation of sphingomyelin pathway and nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit the promotion of colon carcinoma. Ceramide, a metabolite of sphingomyelin, and indomethacin were shown to induce apoptosis in colon carcinoma cells. However, the mechanisms of ceramide- and indomethacin-induced apoptosis in the colon carcinoma cells are not clearly elucidated. Recent studys showed that indomethacin-induced apoptosis in colon cancer cells through the...

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