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501.

Na+-Ca2+ Exchange Curtails Ca2+ before Its Diffusion to Global Ca2+i in the Rat Ventricular Myocyte

Sung-WanAhnChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 4 95-102 (8 pages)

Sung-WanAhnChangMannKo 저
...
- 3,000원
In the heart, Na⁢-Ca2⁢ exchange (NCX) is the major Ca2⁢ extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global [Ca2⁢]i raised during activation. However, if NCX locates in the close proximity to the ryanodine receptor, then NCX would curtail Ca2⁢ before its diffusion to global Ca2⁢i. This will result in a global [Ca2⁢]i decrease especially during its ascending phase rather than descending phase. Therefore, NCX would...
502.

Ca2+-induced Ca2+ Release from Sarcoplasmic Reticulum Negatively Regulates Myocytic ANP Release in Beating Rabbit Atria

DanLi, HeXiuQuan, JinFuWen, JingYuJin, SungHunPark, SunYoungKim, SungZooKim, KyungWooCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 3 87-94 (8 pages)

DanLi, HeXiuQuan, JinFuWen, JingYuJin, SungHunPark, SunYoungKim, SungZooKim, KyungWooCho 저
...
- 3,000원
It is not clear whether Ca2⁢-induced Ca2⁢ release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine increased ANP release, indicating that Ca2⁢ entry via voltage-gated L-type Ca2⁢ channel activation decreases ANP release. The purpose of the present study was two-fold: to define the role of SR Ca2⁢ release in the regulation of ANP release and whether Ca2⁢...
503.

Mechanisms of Myotonic Dystrophies 1 and 2

TimchenkoLubov 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 1 1-8 (8 pages)

TimchenkoLubov 저
...
- 3,000원
Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2) expansions. In DM1, CTG repeats are located within the 3' untranslated region of myotonin protein kinase (DMPK) gene on chromosome 19q. DM2 is caused by expansion of CCTG repeats located in the first intron of a gene coding for zinc finger factor 9 on chromosome 3q. The CTG and CCTG expansions are...
504.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
...
- 3,000원
Heat shock (43oC for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a...
505.

Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 6 101-110 (10 pages)

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 저
...
- 3,000원
Voltage-sensitive release mechanism was pharmacologically dissected from the Ca2⁢-induced Ca2⁢ release in the SR Ca2⁢ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR Ca2⁢ release process was monitored by using forward-mode Na⁢-Ca2⁢ exchange after restriction of the interactions between Ca2⁢ from SR and Na⁢-Ca2⁢ exchange within micro-domains with heavy cytosolic Ca2⁢ buffering with 10 mM BAPTA. During...
506.

Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced

ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 7 43-50 (8 pages)

ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 저
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- 3,000원
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against PMNs. Therefore, we hypothesized that amrinone could attenuate PMNs-induced cardiac dysfunction by suppression of reactive oxygen species (ROS) produced fby PMNs. In the present study, we examined the effects of amrinone on isolated ischemic (20 min) and reperfused...
507.

Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 6 33-41 (9 pages)

JaeBoumYoum, Su-HyunJo, ChaeHunLeem, Won-KyungHo, YungE. 저
...
- 3,000원
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels, pumps, exchangers, and changes of intracellular ion concentration. Changes in membrane excitability and Ca2⁢ transients could then be calculated. In the model, the major ion channels responsible for the stretch-induced changes in electrical activity were the stretch-activated channels (SACs)....
508.

Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure

JaeyoungCho, Sang-HyunLee, GeonHeeLee, WanjooChun, Yee-TaePark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 3 17-20 (4 pages)

JaeyoungCho, Sang-HyunLee, GeonHeeLee, WanjooChun, Yee-TaePark 저
...
- 1,500원
PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN as a tumor suppressor has been well studied, little is known about signaling mechanisms regulating expression and/or activity of PTEN in the central nervous system. In this study, we investigated whether PTEN expression is regulated by sensory deprivation. P5 rat pups were unilaterally...
509.

Antagonists of NMDA Receptor, Calcium Channel and Protein Kinase C Potentiate Inhibitory Action of Morphine on Responses of Rat Dorsal Horn Neuron

HongKeeShin, YeonSukKim, JongHunJun, SeoEunLee, JaeHwaKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 1 251-254 (4 pages)

HongKeeShin, YeonSukKim, JongHunJun, SeoEunLee, JaeHwaKim 저
...
- 1,500원
The present study was designed to examine whether the co-application of morphine with Ca2⁢ channel antagonist (Mn2⁢, verapamil), N-methyl-D-aspartate (NMDA) receptor antagonist (2-amino-5-phosphonopentanoic acid[AP5], Mg2⁢) or protein kinase C inhibitor (H-7) causes the potentiation of morphine- induced antinociceptive action by using an in vivo electrophysiological technique. A single iontophoretic application of morphine or an antagonist alone induced weak inhibition of wide...
510.

Fuctional Relationship between Rate of Fatty Acid Oxidation and Carnitine Palmitoyl Transferase I Activity in Various Rat Tissues

Yu-LeeCho, Kyung-OhDo, Tae-DongKwon, Eung-ChanJang, Keun-MiLee, Suck-KangLee, Jong-YeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 3 207-210 (4 pages)

Yu-LeeCho, Kyung-OhDo, Tae-DongKwon, Eung-ChanJang, Keun-MiLee, Suck-KangLee, Jong-YeonKim 저
...
- 1,500원
muscle followed by liver. Brain tissue showed the lowest CPT I activity as well as lipid oxidation rate, although the values were not significantly different from those of kidney and white gastrocnemius muscle. Therefore, lipid oxidation rate was highly(p＜0.001) related to CPT I activity. Lipid oxidation rate is variable, depending on tissue types, and is highly (p＜0.001) related to CPT I activity. CPT I activity may be a good marker to indicate lipid oxidation capacity in various tissues.

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