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541.

Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats

JongUnLee, SungsuLee, SunmiKim, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 9 121-126 (6 pages)

JongUnLee, SungsuLee, SunmiKim, WonJungLee 저
...
- 3,000원
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left and right ventricular (LV, RV) hypertrophy, respectively. The mRNA expression of aldosterone synthase and adrenomedullin in LV and RV was determined by reverse transcription-polymerase chain reaction. The expression of aldosterone synthase...
542.

Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 5 93-100 (8 pages)

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 저
...
- 3,000원
Effects of oxidized low-density lipoprotein (ox-LDL), l-α-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca2⁢ concentration were examined in mouse endothelial cells by measuring intracellular Ca2⁢ concentration ([Ca2⁢]i) with fura 2-AM and reverse transcription-polymerase chain reaction (RT-PCR). LPC increased [Ca2⁢]i under the condition of 1.5 mM [Ca2⁢]o but did not show any effect under the nominally Ca2⁢-free condition. Even after the store...
543.

The Inhibitory Effect of Opioid on the Hyperpolarization-Activated Cation Currents in Rat Substantia Gelatinosa Neurons

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 2 373-380 (8 pages)

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 저
...
- 3,000원
The action of opioid on the hyperpolarization-activated cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents in a subgroup of neurons. The half-maximal activation and the reversal potential of the current were compatible to neuronal Ih. DAMGO (1μM), a selective- opioid agonist, reduced the amplitude of Ih reversibly. This reduction was...
544.

Lipopolysaccharide Inhibits Proliferation of the Cultured Vascular Smooth Muscle Cells by Stimulating Inducible Nitric Oxide Synthase and Subsequent Activation of Guanylate Cyclase

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 7 343-351 (9 pages)

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 저
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- 3,000원
This study was undertaken to investigate the mechanism of lipopolysaccharide (LPS) and nitric oxide (NO) as a regulator of vascular smooth muscle cell (VSMC) proliferation. VSMC was primarily cultured from rat aorta and confirmed by the immunocytochemistry with anti-smooth muscle myosin antibody. The number of viable VSMCs were counted, and lactate dehydrogenase (LDH) activity was measured to assess the degree of cell death. Concentrations of nitrite in the culture medium were measured as an...
545.

Differentiation Induction of Dendritic Cell Phenotypes from Human Leukemic Cell Lines

Dae-HeuiLee, JaeSunPark, Wan-KyuEo, WooMiKim, KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 11 79-86 (8 pages)

Dae-HeuiLee, JaeSunPark, Wan-KyuEo, WooMiKim, KooilKang 저
...
- 3,000원
Recent clinical studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (ATRA). However, most patients who receive continuous treatment with ATRA relapse and develop ATRA-resistant leukemia. Dendritic cells (DCs) are important antigen-presenting cells in the development of antileukemic T-cell responses. In this study, we investigated the strategies to overcome ATRA resistance of APL...
546.

Increased Expression of Nitric Oxide Synthases in Left and Right Ventricular Hypertrophy

JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 9 65-70 (6 pages)

JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 저
...
- 3,000원
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by...
547.

Role of NF-κB Binding Sites in the Regulation of Inducible Nitric Oxide Synthase by Tyrosine Kinase

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 8 55-63 (9 pages)

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 저
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- 3,000원
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon-γ (IFN-γ) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide synthase (iNOS) gene. To investigate the exact intracellular signaling pathway of the regulation of iNOS gene transcription by LPS plus IFN-γ, the effects of protein tyrosine kinase (PTK) inhibitor and protein kinase C (PKC) inhibitors on NO production, iNOS mRNA expression, nuclear...
548.

Role of Angiotensin II and Nitric Oxide in the Rat Paraventricular Nucleus

Eun-KyoungYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 6 41-46 (6 pages)

Eun-KyoungYang 저
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- 3,000원
To investigate the mutual relationship between angiotensin II (Ang II) and nitric oxide (NO) in paraventricular nucleus (PVN), Ang II receptor type Ia (AT1A), type Ib (AT1B), endothelial constitutive nitric oxide synthase (ecNOS), and neuronal constitutive nitric oxide synthase (ncNOS) mRNA levels of rat PVN were measured after unilateral carotid artery ligation. AT1A and AT1B mRNA levels were markedly elevated 6 hrs after unilateral carotid artery ligation. Losartan injection (10μg/0.3μl)...
549.

Comparative Effects of PKB-α and PKC-ζ on the Phosphorylation of GLUT4-Containing Vesicles in Rat Adipocytes

Jong-SikHah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 7 479-486 (8 pages)

Jong-SikHah 저
...
- 3,000원
Insulin stimulates glucose transport in muscle and fat cells by promoting the translocation of glucose transporter (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement of protein kinase B (PKB)/Akt and PKC-ζ, those are known as the downstream target of PI3-kinase in regulation of GLUT4 translocation, is not known yet. An interesting possibility is that these protein kinases phosphorylate GLUT4 directly in this...
550.

p38 MAPK and NF-κB are Required for LPS-Induced RANTES Production in Immortalized Murine Microglia (BV-2)

Sae-ByeolJangKweon-HaengLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 1 339-346 (8 pages)

Sae-ByeolJangKweon-HaengLee 저
...
- 3,000원
Using murine immortalized microglial cells (BV-2), we examined the regulation of RANTES production stimulated by lipopolysaccharide (LPS), focusing on the role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB. The result showed that RANTES (regulated upon activation of normal T cell expressed and secreted) was induced at the mRNA and protein levels in a dose- and time-dependent manner in response to LPS. From investigations of second messenger pathways involved in...

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