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전체 선택해제
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본문검색 결과만 보기
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Altered Electrophysiological Properties of Coronary Artery in Isoprenaline-Induced Cardiac Hypertrophy
NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 7 413-421 (9 pages)
and increase in the open channel noise of KCa channel by TEA were more sensitive in hypertrophy. Kdr current density is significantly reduced in hypertrophy without activation and inactivation kinetics. The sensitivity of Kdr current on 4-AP is significantly increased in hypertrophy. This is the first study to report evidence for alterations of KCa channels and Kdr channels in coronary SMCs with LVH. The findings may provide some insight into mechanism of the reduced coronary reserve in LVH. -
Decreased Expression of Aquaporin-2 Water Channels in the Kidney in Rats Treated with Reserpine
JongUnLee, YoonWhaOh, SunmiKim, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 3 307-313 (7 pages)
Whether there exists a sympathetic neural mechanism regulating the expression of aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats were treated with reserpine (1 mg/kg, IP), and the expression of AQP1-4 proteins was determined in the kidney one day thereafter. Following the treatment with reserpine, the systolic blood pressure measured in a conscious state was significantly decreased in the experimental group compared with that in the control (83⁑8 vs... -
Indomethacin Induces Apoptosis in NCI-H1299 Human Lung Carcinoma Cells
BumShikKim, SoonAeKim, MiJaKim, HeeJaeLee, Seung-JoonPark, Jee-ChangJung, Chang-JuKim, Sung-VinYim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 8 177-181 (5 pages)
the possibility of its application in the chemoprevention of human lung cancer, we have performed MTT assay, TUNEL assay, DAPI staining, and flow cytometric analysis using human lung carcinoma cell line NCI-H1299. Through morphological and biochemical analyses, it was demonstrated that NCI-H1299 cells treated with indomethacin (0.5 mM) exhibit classical apoptotic features. These results suggest that indomethacin induces apoptosis in NCI-H1299 cells and that NSAIDs, including indomethacin, may be... -
Increased Expression of Nitric Oxide Synthases in Left and Right Ventricular Hypertrophy
JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 9 65-70 (6 pages)
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by... -
Altered Delayed Rectifier K+ Current of Rabbit Coronary Arterial Myocytes in Isoproterenol-Induced Hypertrophy
NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 5 33-40 (8 pages)
The main findings of the study are as follows: (1) the KDR current density was decreased without changes of the channel kinetics in isoproterenol-induced hypertrophy; (2) the sensitivity of coronary KDR channels to 4-AP was increased in isoproterenol-induced hypertrophy. From the above results, we suggest for the first time that the alteration of KDR channels may limit vasodilating responses to several stimuli and may be involved in impaired coronary reserve in isoproterenol-induced hypertrophy. -
GLUT Phosphorylation May be Required to GLUT Translocation Mechanism
Jong-SikHah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 8 487-496 (10 pages)
on GLUT2 immunoblot density among the four membrane fractions before and after insulin treatment. Total GLUT2 distributions at PM, LYSO, HDM and LDM were 37.7⁑12.0%, 42.4⁑12.1%, 19.2⁑5.0% and 0.7⁑1.2% in the absence of insulin. Total GLUT2 distribution in the presence of insulin was almost same as that in the absence of insulin. Present data with previous findings suggest that GLUT4 translocation may be attributed to GLUT4 phosphorylation by PKC-ζ but GLUT2 does not... -
Comparative Effects of PKB-α and PKC-ζ on the Phosphorylation of GLUT4-Containing Vesicles in Rat Adipocytes
Jong-SikHah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 7 479-486 (8 pages)
to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement of protein kinase B (PKB)/Akt and PKC-ζ, those are known as the downstream target of PI3-kinase in regulation of GLUT4 translocation, is not known yet. An interesting possibility is that these protein kinases phosphorylate GLUT4 directly in this process. In the present study, PKB-α and PKC-ζ were added exogenously to GLUT4-containing vesicles purified from low density... -
Ritanserin, a 5HT2/1C Receptor Antagonist, Does Not Block Cocaine- Induced Behavioral Alterations and zif268 mRNA Expression in the Striatum of the Rats
EunSangChoeJongYeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 3 355-359 (5 pages)
Cocaine induces immediate early gene expression and behavioral changes by blocking dopamine transporters in the terminals of nigrostriatal neurons in the striatum. The pharmacological role of serotonin 2/1C (5HT2/1C) receptors in cocaine-induced expression of zif268 (NGFI-A, egr1 and Krox-24) mRNA, a member of the zinc finger, was investigated using quantitative in situ hybridization histochemistry in vivo. Behavioral alterations induced by cocaine were also monitored in relation with blockade... -
Glucose/Oxygen Deprivation Induces Release of [3H]5-hydroxytryptamine Associated with Synapsin 1 Expression in Rat Hippocampal Slices
EunMiPark, SangHuiChu, KyungEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 2 347-353 (7 pages)
It has been well documented that a massive release of not only glutamate but also other neurotransmitters may modulate the final responses of nerve cells to the ischemic neuronal injury. But there is no information regarding whether the release of monoamines is directly associated with synaptic vesicular proteins under ischemia. In the present study, it was investigated whether synapsin 1, syntaxin and SNAP-25 are involved in the release of 5-hydroxytryptamine ([3H]5-HT) in glucose/oxygen... -
Changes of the Level of G Protein α-subunit mRNA by Withdrawal from Morphine and Butorphanol
SeikwanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 4 291-299 (9 pages)
Morphine or butorphanol was continuously infused into cerebroventricle (i.c.v.) with the rate of 26 nmol/ μl/h for 3 days, and the withdrawal from opioid was rendered 7 hrs after the stopping of infusion. The expression of physical dependence produced by these opioids was evaluated by measuring the naloxone- precipitated withdrawal signs. The withdrawal signs produced in animals dependent on butorphanol (kappa opioid receptor agonist) were similar to those of morphine (mu opioid receptor...
