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561.

Cholinergic Activity Related to Cardiovascular Regulation in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

Seok-YongLeeSang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 4 29-34 (6 pages)

Seok-YongLeeSang-BokLee 저
...
- 3,000원
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to clarify the mechanisms of cholinergic hyperactivity in RVLM of the SHR, we studied the activities of enzymes that participate in the biosynthesis and degradation of acetylcholine (ACh) and the density of muscarinic receptors in RVLM of the 14- to...
562.

Modulation of ATP-Induced Activation of the Muscarinic K+ Channel Activity by Protein Kinase C

Yang-MiKim, Hong-KiPark, Jae-HeeHan, Choon-OkPark, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 11 743-753 (11 pages)

Yang-MiKim, Hong-KiPark, Jae-HeeHan, Choon-OkPark, Seong-GeunHong 저
...
- 4,000원
The atrial acetylcholine-activated K⁢ (KACh) channel is gated by the pertussis toxin-sensitive inhibitory G (GK) protein. Earlier studies revealed that ATP alone can activate the KACh channel via transphosphorylation mediated by nucleoside-diphosphate kinase (NDPK) in atrial cells of rabbit and guinea pig. This channel can be activated by various agonists and also modulated its function by phosphorylation. ATP-induced KACh channel activation (AIKA) was maintained in the presence of the...
563.

Sensitivity of Rabbit Cerebral Artery to Serotonin is Increased with the Moderate Increase of Extracellular K+

SukHyoSuh, SungJinPark, JaiYoungChoi, JaeHoonSim, YoungChulKim, SungJoonKim, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 6 695-703 (9 pages)

SukHyoSuh, SungJinPark, JaiYoungChoi, JaeHoonSim, YoungChulKim, SungJoonKim, InsukSo, KiWhanKim 저
...
- 3,000원
[K⁢]O can be increased under a variety of conditions including subarachnoid hemorrhage. The increase of [K⁢]O in the range of 5∼15 mM may affect tensions of blood vessels and can change their sensitivity to various vasoactive substances. Therefore, it was examined in the present study whether the sensitivity of cerebral arteries to vasoactive substances can be changed with the moderate increase of [K⁢]O, using Mulvany-type myograph and [Ca2⁢]c measurement. The...
564.

Effects of Neonatal Footshock Stress on Glucocorticoid and 5- HT2A/2C Receptor Bindings and Exploratory Behavior

DongGooKim, SeoulLee, DongWonKang, JongSuLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 4 677-685 (9 pages)

DongGooKim, SeoulLee, DongWonKang, JongSuLim 저
...
- 3,000원
To investigate the effects of neonatal stress on behavior and neurochemistry, rats were exposed to the footshock stress on postnatal day (PND) 14 or PNDs 14 and 21. Rats were exposed to uncontrollable electric shocks delivered to the floor with a constant current (0.8 mA) for 5 sec period. Daily sessions consisted of 60 trials on a random time schedule with an average of 55 sec. The first exposure to footshocks on PND 14 decreased body weight gain for 1 day. However, the second exposure to...
565.

Effects of Dopamine and Haloperidol on Morphine-induced CREB and AP-1 DNA Binding Activities in Differentiated SH-SY5Y Human Neuroblastoma Cells

Soo-kyungKimGee-younKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 3 671-676 (6 pages)

Soo-kyungKimGee-younKwon 저
...
- 3,000원
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and...
566.

Regulation of Salt and Volume Transport along the Nephron during Acute Systolic Hypertension

AliciaA.McDonough, YibinZhang, ClaraE.Magyar, AustinK.Mircheff 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 1 541-547 (7 pages)

AliciaA.McDonough, YibinZhang, ClaraE.Magyar, AustinK.Mircheff 저
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- 3,000원
567.

Pharmacological Characterization of Synthetic Tetrahydroisoquinoline Alkaloids, YS 51 and YS 55, on the Cardiovascular System

Ki-ChurlChang, Young-JinKang, Young-SooLee, Won-SeogChong, Hye-SookYun-Choi, Duck-HyongLee, Jae-ChunRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 8 461-469 (9 pages)

Ki-ChurlChang, Young-JinKang, Young-SooLee, Won-SeogChong, Hye-SookYun-Choi, Duck-HyongLee, Jae-ChunRyu 저
...
- 3,000원
in which pEC50 were 5.89⁢0.21 and 5.93⁢0.19, respectively. Propranolol (30 nM) did not affect the relaxation-response curves to YS 51 and YS 55. Concentration-response curves to PE were shifted to right by the pretreatment with YS 51 or YS 55. The pA2 values of YS 51 and YS 55 showed 6.05⁢0.24 and 5.88⁢0.16, respectively. Both probes relaxed KCl (65.4 mM)-contracted aorta and inhibited CaCl2-induced contraction of PE-stimulated endothelium- denuded rat thoracic aorta in...
568.

Rapid Induction of mRNA for Prostaglandin H Synthase in Ovine Meningeal Fibroblasts

MyeongJinNam, ClaraThore, DavidBusija 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 5 435-441 (7 pages)

MyeongJinNam, ClaraThore, DavidBusija 저
...
- 3,000원
We examined effects of interleukin 1α (IL1α) and phorbol 12, 13 dibutyrate (PDB), an activator of protein kinase C, on mRNA for Prostaglandin H synthase (PGHS) and prostanoid production in cultured ovine meningeal fibroblasts. Immuno- and morphologically-identified fibroblasts were derived from cerebral cortex and white matter from fetal lambs (approximately 120 days gestation) and grown to confluence on glass coverslips in 12 well plates. Levels of prostaglandin F2α and the stable...
569.

In Vitro Cytotoxicity of Novel Platinum(II) Coordination Complexes Containing Diaminocyclohexane and Diphenylphosphines

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 15 395-401 (7 pages)

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 저
...
- 3,000원
We have synthesized new platinum(II) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of [Pt(trans-l-dach)(DPPP)]·2NO3 (KHPC-001) and [Pt(trans-l-dach)(DPPE)]·2NO3 (KHPC-002) was evaluated and compared on various P-388 cancer cell lines and porcine kidney cell line (LLC-PK1). The new platinum...
570.

Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat

Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 7 323-330 (8 pages)

Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 저
...
- 3,000원
of propranolol, the concentration response curves of YS 49 and YS 51 shifted to the right and resulted in pA2 values of 8.07⁑0.84 and 7.93⁑0.11, respectively. The slope of each compound was not deviated from unity, indicating that these chemicals are highly competitive at the cardiac ㄂-adrenoceptors. YS 49, YS 51, and higenamine showed ㄁-adrenoceptor affinity in rat brain, in which the dissociation constant (Ki) was 2.75, 2.81, and 1.02 ㄍM, respectively. It is...

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