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591.

Caffeic Acid Phenethyl Ester Inhibits the PKC-Induced IL-6 Gene Expression in the Synoviocytes of Rheumatoid Arthritis Patients

Gang-MinHur, Yin-BangHwang, Jae-HeunLee, So-HyunBae, Ji-SunPark, Choong-JaeLee, Jeong-HoSeok 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 11 363-368 (6 pages)

Gang-MinHur, Yin-BangHwang, Jae-HeunLee, So-HyunBae, Ji-SunPark, Choong-JaeLee, Jeong-HoSeok 저
...
- 3,000원
in the pathogenesis and treatment of rheumatoid arthritis (RA), the phorbol 12-myristate 13-acetate (PMA)-induced IL-6 gene expression and the effect of caffeic acid phenethyl ester (CAPE) on the PMA-induced IL-6 gene expression were investigated in human fibroblast-like synoviocytes (FLSs). Synovial tissue samples were obtained from rheumatoid arthritis patients, and FLSs were isolated. The cells were stimulated with PMA (100 nM) for 6 hrs to induce IL-6 gene. The cells were pretreated with CAP...
592.

Inhibitory Effect of Esculetin on the Inducuble Nitric Oxide Synthase Expression in TNF-stimulated 3T3-L1 Adipocytes

Jeong-YehYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 7 283-287 (5 pages)

Jeong-YehYang 저
...
- 1,500원
While nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) is beneficial for host survival, it is also detrimental to the host. Thus, regulation of iNOS gene expression may be an effective therapeutic strategy for the prevention of unwanted reactions at various pathologic conditions. During the screening process for the possible iNOS regulators, we observed that esculetin is a potent inhibitor of cytokine-induced iNOS expression. The treatment of 3T3-L1 adipocytes with the tumor...
593.

Influence of Bradykinin on Catecholamine Release from the Rat Adrenal Medulla

Dong-YoonLim, Il-HwanKim, Gwang-MoonNa, Moo-JinKang, Ok-MinKim, Deok-HoChoi, Young-WooKi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 7 231-238 (8 pages)

Dong-YoonLim, Il-HwanKim, Gwang-MoonNa, Moo-JinKang, Ok-MinKim, Deok-HoChoi, Young-WooKi 저
...
- 3,000원
of cholinergic receptors and membrane depolarization from the isolated perfused model of the rat adrenal glands, and to elucidate its mechanism of action. Bradykinin (3⁓10⁣8 M) alone produced a weak secretory response of the CA. however, the perfusion with bradykinin (3⁓10⁣8 M) into an adrenal vein of the rat adrenal gland for 90 min enhanced markedly the secretory responses of CA evoked by ACh (5.32⁓10⁣3 M), excess K⁢ (5.6⁓10⁣2 M, a membrane...
594.

Involvement of NAD(P)H Oxidase in a Potential Link between Diabetes and Vascular Smooth Muscle Cell Proliferation

HyeYoungJeong, MiRanYun, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 9 103-109 (7 pages)

HyeYoungJeong, MiRanYun, ChiDaeKim 저
...
- 3,000원
The cellular mechanisms that contribute to the acceleration of atherosclerosis in diabetes are poorly understood. Therefore, the potential mechanisms involved in the diabetes-dependent increase in vascular smooth muscle cell (VSMC) proliferation was investigated. Using primary culture of VSMC from streptozotocin-induced diabetic rat aorta, cell proliferation assay showed two-fold increase in cell number accompanied with enhanced superoxide generation compared to normal VSMC, 2 days after...
595.

Promoting Effect of a Mixture of 8 Herbal Extracts (SPELA 707) on Hair Growth

Eun-YoungChoi, Soo-NamPark, Sung-ukPark, SeongwonChoi, Byungin-Ro, Myung-HeeChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 7 91-96 (6 pages)

Eun-YoungChoi, Soo-NamPark, Sung-ukPark, SeongwonChoi, Byungin-Ro, Myung-HeeChung 저
...
- 3,000원
In Korean folk medicine, several herbs, Glycyrrhizae Radix, Persicae Semen, Salviae Radix, Angelicae Gigantis Radix, Zanthoxyli Fructus, Ginseng Radix Alba, Cnidii Rhizoma, and Carthami Flos, are known to enhance blood circulation and have wound healing or anti-inflammatory effects. These pharmacological actions prompted us to investigate whether these herbs might stimulate hair growth. Thus, using a mixture of their extracts called SPELA 707, we investigated their effects and found that SPELA...
596.

Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking α-Calcitonin Gene-Related Peptide

JonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 4 299-304 (6 pages)

JonghoLee 저
...
- 3,000원
Calcitonin gene-related peptide (CGRP) expressing neurons are distributed widely throughout the central and peripheral nervous systems. Due to its distribution and pharmacological studies, CGRP has been implicated to be involved in anxiety, fear and depression. In this study, αCGRP-knockout mice were used to assess the consequences of removing this neuropeptide to the mice behaviors. αCGRP-knockout mice performed equally as well as wild type mice in the light-dark transition test and in the...
597.

Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats

SeoulLee, TieYuanZhang, GunTaeKim, HeeSooKim, JongDooLee, JeongWonJahng, DongGooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 3 293-297 (5 pages)

SeoulLee, TieYuanZhang, GunTaeKim, HeeSooKim, JongDooLee, JeongWonJahng, DongGooKim 저
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- 1,500원
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50μg/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition,...
598.

Influence of Tacrine on Catecholamine Secretion in the Perfused Rat Adrenal Gland

Seok-JeongJang, Won-HoYang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 6 207-214 (8 pages)

Seok-JeongJang, Won-HoYang, Dong-YoonLim 저
...
- 3,000원
The present study was designed to clarify whether tacrine affects the release of catecholamines (CA) from the isolated perfused model of rat adrenal gland or not and to elucidate the mechanism of its action. Tacrine (3⁓10⁣5∼3⁓10⁣4 M) perfused into an adrenal vein for 60 min inhibited CA secretory responses evoked by ACh (5.32⁓10⁣3 M), DMPP (a selective neuronal nicotinic agonist, 10⁣4 M for 2 min) and McN-A-343 (a selective muscarinic M1-agonist,...
599.

Molecular Mechanism of Pancreatic Bicarbonate Secretion

MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 1 131-138 (8 pages)

MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 저
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- 3,000원
Thanks to recent progress in availability of molecular and functional techniques it became possible to search for the basic molecular and cellular processes that mediate and control HCO3⁣ and fluid secretion by the pancreatic duct. The coordinated action of various transporters on the luminal and basolateral membranes of polarized epithelial cells mediates the transepithelial HCO3⁣ transport, which involves HCO3⁣ absorption in the resting state and HCO3⁣ secretion in the...
600.

Effects of Pretreatment of Serotonin Synthesis Inhibitor p-chlorophenylalanine on Lipopolysaccharide-induced Anorexia in Rats

So-youngPark, ByungSuckKim, SeoungSookBack 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 3 133-138 (6 pages)

So-youngPark, ByungSuckKim, SeoungSookBack 저
...
- 3,000원
In the present study, we investigated the effect of pretreatment of p-chlorophenylalanine (PCPA), inhibitor of serotonin synthesis, on lipopolysaccharide (LPS)-induced anorexia in rats. First of all, effects of PCPA injection on food intake and body weight in rats were investigated. During 4 days of PCPA injection (300 mg/kg BW once a day), food intake was decreased by 33% and daily gain in body weight was inhibited compared with controls. Twenty-four hours after last PCPA injection, food...

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