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671.

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice

SunAeHwang, ChiDaeKim, WonSukLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 11 101-110 (10 pages)

SunAeHwang, ChiDaeKim, WonSukLee 저
...
- 3,000원
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5...
672.

Inhibitory effects of 2,6-di-tert-butyl-4-hydroxymethylphenol on asthmatic responses to ovalbumin challenge in conscious guinea pigs

Seul-YongJeong, Ji-YunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 9 81-89 (9 pages)

Seul-YongJeong, Ji-YunLee 저
...
- 3,000원
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical...
673.

Cilostazol attenuates kainic acid-induced hippocampal cell death

Young-SeopPark, ZhenJin, EunAeJeong, Chin-okYi, JongYoulLee, InSungPark, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 7 63-70 (8 pages)

Young-SeopPark, ZhenJin, EunAeJeong, Chin-okYi, JongYoulLee, InSungPark, GuSeobRoh 저
...
- 3,000원
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol’s effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against...
674.

Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing’s syndrome

MinaKim, Hae-AhmLee, Hyun-MinCho, Seol-HeeKang, EunjoLee, InKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 3 23-33 (11 pages)

MinaKim, Hae-AhmLee, Hyun-MinCho, Seol-HeeKang, EunjoLee, InKyeomKim 저
...
- 4,000원
Cushing’s syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic hormone (ACTH; 40 ng/kg/day) to Sprague-Dawley rats by subcutaneous infusion with osmotic mini-pumps. We...
675.

The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain

MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)

MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 저
...
- 3,000원
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced...
676.

Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion

Kyung-OkCho, Seul-KiKim, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 9 643-650 (8 pages)

Kyung-OkCho, Seul-KiKim, SeongYunKim 저
...
- 3,000원
Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of Wistar and Sprague–Dawley (SD) rats subjected to permanent bilateral common carotid artery occlusion (BCCAo). Eight-week old male Wistar and SD rats underwent BCCAo, followed by a reference memory test using a five-radial arm maze with tactile cues. Continuous monitoring of cerebral...
677.

Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase

ZhiliXu, HanyeLiang, MingboZhang, XiaojunTao, DeqiangDou, LipingHu, TingguoKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 5 609-616 (8 pages)

ZhiliXu, HanyeLiang, MingboZhang, XiaojunTao, DeqiangDou, LipingHu, TingguoKang 저
...
- 3,000원
Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in vitro and in vivo. The experiment of smooth muscle contraction directly monitored the contractions of the isolated jejunal segment (IJS) in different contractile states, and the effects of ardipusilloside-I on myosin were measured in the presence of Ca2+-calmodulin using the activities of 20...
678.

Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins

SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 8 531-546 (16 pages)

SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 저
...
- 4,500원
Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24,and 36 h to induce TLR-4 activation. The...
679.

The activation of α2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality

Sung-SuKim, Soo-HyunPark, Jae-RyungLee, Jun-SubJung, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 5 495-507 (13 pages)

Sung-SuKim, Soo-HyunPark, Jae-RyungLee, Jun-SubJung, Hong-WonSuh 저
...
- 4,200원
The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 µg/27 µl) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine (5 µg/5 µl) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with...
680.

Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain

SukjaeJoshuaKang, SiyongKim, JaehyunLee, ChuljungKwak, KyungminLee, MinZhuo, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 4 487-493 (7 pages)

SukjaeJoshuaKang, SiyongKim, JaehyunLee, ChuljungKwak, KyungminLee, MinZhuo, Bong-KiunKaang 저
...
- 3,000원
The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the ACC, show that the ACC can modulate mechanical hyperalgesia. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC in a model of chronic inflammatory pain to assess their motivational effect in the...

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