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61.

Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells

VanAnhVo, Jae-WonLee, Ji-YoungKim, Jun-HoPark, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 11 79-86 (8 pages)

VanAnhVo, Jae-WonLee, Ji-YoungKim, Jun-HoPark, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 저
...
- 3,000원
lipopo-lysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In the present study, CG significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2 and the protein expression of iNOS and COX-2. CG also inhibited LPS-induced secretion of pro-inflammatory cytokines, IL-1β and TNF-α. In addition, CG significantly suppressed LPS-induced degradation of IκB. To elucidate the underlying mechanism by which CG exerts its anti-inflammatory...
62.

Bcl-2 Knockdown Accelerates T Cell Receptor-Triggered Activation-Induced Cell Death in Jurkat T Cells

Yun-JungLee, TaeJoonWon, KyeongEunHyung, MiJiLee, Young-hyeMoon, IkHeeLee, ByungSungGo, KwangWooHwang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 10 73-78 (6 pages)

Yun-JungLee, TaeJoonWon, KyeongEunHyung, MiJiLee, Young-hyeMoon, IkHeeLee, ByungSungGo, KwangWooHwang 저
...
- 3,000원
cancer. Death receptors sense extracellular signals to induce caspase-mediated apoptosis. Acting upstream of CED-3 family proteases, such as caspase-3, Bcl-2 prevents apoptosis. Using short hairpin RNAs (shRNAs), we suppressed Bcl-2 expression in Jurkat T cells, and this increased TCR-triggered AICD and enhanced TNFR gene expre-ssion. Also, knockdown of Bcl-2 in Jurkat T cells suppressed the gene expression of FLIP, TNF receptor-associated factors 3 (TRAF3) and TRAF4. Furthermore, suppressed B
63.

Nitric Oxide-Induced Apoptosis of Human Dental Pulp Cells Is Mediated by the Mitochondria-Dependent Pathway

MinYoungPark, YeonJinJeong, GiChangKang, Mi-HwaKim, SunHunKim, Hyun-JuChung, JiYeonJung, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 3 25-32 (8 pages)

MinYoungPark, YeonJinJeong, GiChangKang, Mi-HwaKim, SunHunKim, Hyun-JuChung, JiYeonJung, WonJaeKim 저
...
- 3,000원
a dose- and time-dependent manner. We investigated the in vitro effects of nitric oxide on apoptosis of cultured HDPCs. Cells showed typical apoptotic morphology after exposure to SNP. Besides, the number of Annexin V positive cells was increased among the SNP-treated HDPCs. SNP enhanced the production of reactive oxygen species (ROS), and N-acetylcysteine (NAC) ameliorated the decrement of cell viability induced by SNP. However, a soluble guanylate cyclase inhibitor (ODQ) did not inhibited the...
64.

Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells

MyeongJaeLee, HyunJuSong, JunYeongJeong, SunYoungPark, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 12 81-87 (7 pages)

MyeongJaeLee, HyunJuSong, JunYeongJeong, SunYoungPark, UyDongSohn 저
...
- 3,000원
in vitro. Epithelial cells obtained from cat esophagus were cultured. When the cells were exposed to acid for 2 h, cell viability was decreased to 36%. Pretreatment with 50 ՌM QGC for 2 h prevented the reduction in cell viability. QGC also inhibited the productions of intracellular ROS by inflammatory inducers such as acid, lipopolysaccharide, indomethacin and ethanol. QGC significantly increased the activities of superoxide dismutase (SOD) and catalase, and also induced the expression of...
65.

Comparison of Ectopic Gene Expression Methods in Rat Neural Stem Cells

WoosukKim, JiHyeonKim, Sun-YoungKong, Min-HyePark, UyDongSohn, Hyun-JungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 4 23-30 (8 pages)

WoosukKim, JiHyeonKim, Sun-YoungKong, Min-HyePark, UyDongSohn, Hyun-JungKim 저
...
- 3,000원
Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology, genes or siRNAs need to be transfected. However, it is difficult to transfect ectopic genes into NSCs. Thus to identify the suitable method to achieve high transfection efficiency, we compared lipid transfection, electroporation, nucleofection and retroviral transduction. Among the methods that we tested, we...
66.

Generation of CD2＋CD8＋ NK Cells from c-Kit＋ Bone Marrow Cells in Porcine

KyuHeeLim, Ji-HuiHan, YoonSeokRoh, BumseokKim, Jung-KeeKwon, MyoungJoYou, HoJaeHan, SohailEjaz6, Chang-WonKang, Jong-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 3 167-174 (8 pages)

KyuHeeLim, Ji-HuiHan, YoonSeokRoh, BumseokKim, Jung-KeeKwon, MyoungJoYou, HoJaeHan, SohailEjaz6, Chang-WonKang, Jong-HoonKim 저
...
- 3,000원
Natural killer (NK) cells provide one of the initial barriers of cellular host defense against pathogens, in particular intracellular pathogens. Because bone marrow-derived hematopoietic stem cells (HSCs), lymphoid protenitors, can give rise to NK cells, NK ontogeny has been considered to be exclusively lymphoid. Here, we show that porcine c-kit＋ bone marrow cells (c-kit＋ BM cells) develop into NK cells in vitro in the presence of various cytokines [interleukin (IL)-2, IL-7, IL-15, IL-21, stem...
67.

3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells

Jae-WonLee, ChangJunBae, , Yong-JunChoi, Song-InKim, Nam-HoKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 4 107-112 (6 pages)

Jae-WonLee, ChangJunBae, , Yong-JunChoi, Song-InKim, Nam-HoKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 저
...
- 3,000원
lipopolysaccharide (LPS)-stimulated BV2 microglial cells. THC significantly suppressed LPS-induced excessive production of nitric oxide (NO) and expression of iNOS, which is responsible for the production of iNOS. THC also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1Ղand TNF-Ձin BV2 microgilal cells. Furthermore, THC significantly suppressed LPS-induced degradation of IՊB, which retains NF-ՊB in the cytoplasm. Therefore, THC attenuated...
68.

Microarray Analysis of Gene Expression Profiles in Response to Treatment with Melatonin in Lipopolysaccharide Activated RAW 264.7 Cells

JuYeonBan, BumSikKim, SooCheolKim, DongHwanKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 4 23-30 (8 pages)

JuYeonBan, BumSikKim, SooCheolKim, DongHwanKim, Joo-HoChung 저
...
- 3,000원
to treatment with melatonin in lipopolysaccharide (LPS) activated RAW 264.7 macrophage cells. In addition, eight genes were subjected to real-time reverse transcription polymerase chain reaction (RT-PCR) to confirm the results of the microarray. The cells were treated with LPS or melatonin plus LPS for 24 hr. LPS induced the up-regulation of 1073 genes and the down-regulation of 1144 genes when compared to the control group. Melatonin pretreatment of LPS-stimulated RAW 264.7 cells resulted in th...
69.

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated from Rhus verniciflua in LPS-stimulated BV2 Microglial Cells

Jae-WonLee, Il-YoungCheong, Hae-SungKim, JaeJunLee, Yong-SukLee, Yong-SooKwon, Myong-JoKim, HeeJaeLee, Sung-SooKim, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 2 9-16 (8 pages)

Jae-WonLee, Il-YoungCheong, Hae-SungKim, JaeJunLee, Yong-SukLee, Yong-SooKwon, Myong-JoKim, HeeJaeLee, Sung-SooKim, WanjooChun 저
...
- 3,000원
on lipopoly</I>saccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of cells with DC significantly attenuated LPS-induced NO production, and mRNA and protein expression of iNOS in a concentration- dependent manner. DC also significantly suppressed LPS-induced release of cytokines such as TNF-Ձ and IL-1Ղ. Consistent with the decrease in cytokine release, DC dose-dependently and significantly attenuated LPS-induced mRNA expression of these cytokines. Furthermore, DC...
70.

Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells

DaeGoonYoo, CukSeongKim, SangKiLee, HyoShinKim, EunJungCho, MyoungSooPark, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 4 139-144 (6 pages)

DaeGoonYoo, CukSeongKim, SangKiLee, HyoShinKim, EunJungCho, MyoungSooPark, SangDoLee, JinBongPark, ByeongHwaJeon 저
...
- 3,000원
A549 cells. The phosphorylation of p38 MAPK was increased significantly after 5 minutes of treatment with TNF-Ձ, reaching a maximum level at 10 min which persisted for up to 60 min. However, p38MAPK phosphorylation was markedly suppressed in the Ref-1-overexpressed A549 cells. Taken together, our results appear to indicate that Ref-1 negatively regulates COX-2 expression in response to cytokine stimulation via the inhibition of p38 MAPK phosphorylation. In the lung cancer cell lines, Ref-1...

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