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Contractile and Electrical Responses of Guinea-pig Gastric Smooth Muscle to Bradykinin
Kim, Chul-Soo, Jun, Jae-Yeoul, Kim, Sung-Joon, So, In-Suk, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 5 233-242 (10 pages)
The nonapeptide bradykinin has been shown to exhibit an array of biological activities including relaxation/contraction of various smooth muscles. In order to investigate the effects of bradykinin on the contractility and the electrical activity of antral circular muscle of guinea-pig stomach, the isometric contraction and membrane potential were recorded. Also, using standard patch clamp technique, the Ca2+-activated K currents were recorded to observe the change in cytosolic Ca2+... -
Identification of Adenosine 5 -Tetraphosphate in Rabbit Platelets and its Metabolism in Blood
Lee, Joong-Woo, Jeon, Sang-Jun, Kong, In-Deok, Jeong, Seong-Woo 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 3 217-224 (8 pages)
Adenosine 5 -tetraphosphate (ATPP) was identified and quantified in extracts of rabbit platelets by elution of extracts containing authentic adenosine 5 -tetraphosphate and comparison of retention time with nucleotide standards using high-performance liquid chromatography technique. The amount of adenosine 5 -tetraphosphate was 0.62 nmoles/109 cells which was 62-fold lower than that of ATP but only 10-fold lower than that of ADP. During platelet aggregation induced by thrombin, adenosine 5... -
Effects of Insulin and IGFS on Growth and Functional Differentiation in Primary Cultured Rabbit Kidney Proximal Tubule Cells -Growth and membrane transport-
Han, Ho-Jae, Park, Kwon-Moo, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 1 191-202 (12 pages)
The purpose of this study was to compare effects of insulin and IGFs on growth, apical membrane enzyme activities and membrane transport systems of primary cultured rabbit kidney proximal tubule cells. Results were as follows: 1. Insulin and IGF-I produced significant growth stimulatory effects at 5 X 10-10M. IGF-II(5 X 10 -10 M) did not stimulate significant cell growth. 2. Insulin stimulated the phosphorylation of a 97 KD protein. It was difficult to determine whether this band represents... -
Effects of In Vitro Exposure to Silica on Bioactive Mediator Release by Alveolar Macrophages
Lee, Ji-Hee 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 1 1-12 (12 pages)
a positive control fur the PAF assay increased PAF release by 19 % of total serotonin release. Furthermore, silica also resulted in significant enhancement of the PAF release compared with that in unstimulated (control) cells, i.e., 17.7±5.8% and 24.0±4.9% of total serotonin release at 5 mg/ml and 10 mg/ml silica, respectively, which represents the release of nanomole levels of PAF. Lastly, IL-1 production by alveolar macrophages was analysed following their stimulation with lipopolysaccharide... -
Contribution of Bulk Flow to Transport Mechanisms of the Membranes Surrounding Amniotic Fluid in the Rabbit
Lim, Young-Cheol, Lee, Sang-Jin, Sung, Ho-Kyung 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 8 79-90 (12 pages)
The objective of the present study is to assess the contribution of bulk flow to the regulatory mechanism of amniotic fluid volume and its ionic concentration in the membranes surrounding the amniotic fluid. For quantitative assessment, we prepared 4 kinds of artificial amniotic fIuids (isotonic isovolumetric, hypotonic isovolumetric, isotonic hypervolumetric and hypotonic hypervolumetric ones) by replacing 70% of amniotic fluid of pregnant rabbits with water or normal Tyrode solutions.... -
Cocaine-induced Changes in Functional Connectivities between Simultaneously Recorded Single Neurons in the SI Cortex and the VPL Thalamus of Conscious Rats
Shin, Hyung-Cheul, Park, Hyoung-Jin, Oh, Yang-Seok, Chapin, John K. 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 8 79-92 (14 pages)
a control, but it did not appear to alter the functional connectivities. In general, cocaine-induced changes of the functional interactions were mainly due to the concomitant alterations of the uncorrelated background discharges. These results suggest that the biphasic effects of cocaine on the spontaneously established neural networks among the SI cortical and the VPL thalamic cells of conscious rat were mainly indirect. However, various changes of the functional interactions by different doses... -
Effect of Changing Amniotic Fluid Osmolarity on the Li+ Transport Through the Membrane Surrounding Amniotic Fluid in the Rabbit
Chang, Jin-Keun, Lee, Sang-Jin, Sung, Ho-Kyung 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 2 13-26 (14 pages)
while the injection of mannitol into the maternal vein induced no significant change. From these results it is concluded that: 1) a significant amount of Li+ may leave the amniotic fluid via filtration through the membranes surrounding the amniotic fluid, 2) during hyperosmolar challenge to amniotic fluid, osmotic bulk flow might counteract the filterable loss, and 3) Li+ disappearance might continue even after the volume and osmolarity of the amniotic fluid have recovered to control values. -
Role of Endogenous Nitric Oxide in the Vasorelaxation Induced by High Calcium Environment in vitro
Lee, Jong-Eun, Lee, Byung-Kook, Ahn, Hyun-Taek, Ahn, Byoung-Hee, Kang, Jung-Chaee 대한생리학회 대한생리학회지 6 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 3 123-128 (6 pages)
The present study was undertaken to examine if endogenous nitric oxide is partly responsible for the high calcium induced vasorelaxation in vitro. Isolated porcine coronary arterial rings were suspended in the tissue chamber and their changes in isometric tension were recorded. KCI little affected the vascular tension in the calcium free media, but subsequent addition of cumulative doses of CaCl3 from 1 to 40 mM caused a contraction followed by complete relaxation. The maximum tension was noted... -
Effect of Various Divalent Ions on the Calcium Current of Adrenal Medullary Chromaffin Cells in the Rat
Kim, Jun, Leem, Chae-Hun, Kim, Sang-Jeong 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 2 113-122 (10 pages)
this secretory process. In this study, we explored the effect of divalent cations on VDCC of rat chromaffin cells. Rat (Sprague-Dawley rat, 150-250 gm) chromaffin cells were isolated and cultured. Standard giga seal, whole cell recording techniques were employed to study Ca2+ current with external and internal solutions that could effectively isolate VDCC currents (NMG in external and TEA and Cs2+ in internal solution). The voltage dependence and the inactivation time course of VDCC in our cells... -
A Novel Therapeutic Measure for Metabolic Acidosis with Amino Acids
Kim, Jun, Goo, Yong-Sook, Kim, Sang-Jeong, Park, Sang-Chul, Koh, Chang-Soon 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 9 89-98 (10 pages)
In hypoxic tissue conditions, pyruvate can not enter the Krebs cycle and lactic acid, produced from pyruvate, accumulates to induce lactic acidosis. Pyruvate, However, can also be converted to alanine by glutamate pyruvate transaminase, that could be enhanced by glutamate. Therefore, it would be a fundamental measure to treat the lactic acidosis in tissue hypoxic conditions when one can convert the accumulated lactic acid, through pyruvate, to alanine. To test the above hypothesis, we induced a...


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