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간행물
- CARBON LETTERS(336)
- THE PLANT PATHOLOGY JOURNAL (173)
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY(143)
- 한국전자현미경학회지(137)
- JOURNAL OF VETERINARY SCIENCE(115)
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(102)
- 한국진공학회지(93)
- 식물병연구(77)
- 대한수의학회 학술대회발표집(63)
- 한국재료학회지(61)
- 한국식품영양과학회지(59)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(50)
- 대한화학회지(47)
- 전기전자재료학회논문지(46)
- 한국식품과학회지(46)
- 대한약리학잡지(43)
- 대한생리학회지(39)
- 한국식품저장유통학회지(38)
- 한국자기학회지(36)
- THE KOREAN JOURNAL OF ORTHODONTICS(33)
- 폴리머(32)
- 의학물리(31)
- 한국세라믹학회지(28)
- 한국현미경학회지(27)
- 전기전자재료학회지= THE JOURNAL OF THE KOREAN INSTITUTE OF ELECTRICAL AND ELECTRONIC MATERIAL ENGINEERS(26)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(25)
- 전자공학회논문지. JOURNAL OF THE INSTITUTE OF ELECTRONICS ENGINEERS OF KOREA. SD, 반도체(25)
- 한국결정성장학회지(24)
- 열환경공학(23)
- JOURNAL OF MAGNETICS(22)
- TRANSACTIONS ON ELECTRICAL AND ELECTRONIC MATERIALS(22)
- JOURNAL OF PHOTOSCIENCE: AN INTERNATIONAL JOURNAL OFFICAIL ORGAN OF THE KOREAN SOCIETY OF PHOTOSCIEN(21)
- APPLIED MICROSCOPY(20)
- 천문학회보(19)
- 대한방사선치료기술학회지(18)
- JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE(17)
- 신경정신의학(17)
- 한국우주과학회지(16)
- JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY(15)
- 전기학회논문지. THE TRANSACTIONS OF THE KOREAN INSTITUTE OF ELECTRICAL ENGINEERS. C/ C, 전기물성-응용부문(15)
- 한국광물학회지(15)
- FIBERS AND POLYMERS(14)
- MACROMOLECULAR RESEARCH(14)
- 한국정밀공학회지(14)
- FOOD SCIENCE AND BIOTECHNOLOGY(13)
- 방사선방어학회지(13)
- 예술인문사회융합멀티미디어논문지(13)
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- JOURNAL OF DENTAL IMPLANT RESEARCH(12)
- KOREAN CHEMICAL ENGINEERING RESEARCH(12)
- 공업화학(12)
- 마이크로전자 및 패키징 학회지(12)
- 멤브레인(12)
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- JOURNAL OF INFORMATION DISPLAY(11)
- 대한치료방사선과학회지(11)
- 목재공학(11)
- 한국농화학회지(11)
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- INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING(10)
- NUCLEAR ENGINEERING AND TECHNOLOGY : AN INTERNATIONAL JOURNAL OF THE KOREAN NUCLEAR SOCIETY(10)
- 대한소아치과학회지(10)
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- 대한치과보존학회지(9)
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- 동물학회지(9)
- 열처리공학회지(9)
- 전기학회논문지= THE TRANSACTIONS OF THE KOREAN INSTITUTE OF ELECTRICAL ENGINEERS(9)
- 펄프 종이기술(9)
- 한국조리과학회지(9)
- JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY(8)
- JOURNAL OF PLANT BIOLOGY(8)
- THE KOREAN JOURNAL OF PARASITOLOGY(8)
- 대한용접학회지(8)
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Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not been well characterized. We observed decreased expression of GS28 in rat ischemic hippocampus. In this study, we examined the role of GS28 and its molecular mechanisms in neuronal (SK-N-SH) cell death induced by hydrogen peroxide (H2O2). GS28 siRNA-transfected cells treated with H2O2 showed... -
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Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the... -
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Na-HyunKim, Kyu-SangPark, JoonHyungSohn, Byung-IlYeh, ChangMannKo, InDeokKong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 9 61-65 (5 pages)
P2Y receptors are metabotropic G-protein-coupled receptors, which are involved in many important biologic functions in the central nervous system including retina. Subtypes of P2Y receptors in retinal tissue vary according to the species and the cell types. We examined the molecular and pharmacologic profiles of P2Y purinoceptors in retinoblastoma cell, which has not been identified yet. To achieve this goal, we used Ca2＋ imaging technique and western blot analysis in WERI-Rb-1 cell, a human... -
Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
YongJinKim, EunAeKim, UyDongSohn, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 14 441-447 (7 pages)
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities against human renal cancer Caki-2 and leukemic cancer HL-60 in the MTT assay. Some compounds (12, 15, and 16) showed stronger cytotoxicity than B13 and C6-ceramide against both tumor cell lines, and compound (12) gave the most potent activity with IC50 values of 36 and 9</SUB>ՌM,... -
Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
Sun-YoungLee, Kyoung-WonKo, Won-KyungKang, Yun-JeongChoe, Yoon-HyoungKim, In-KyungKim, JinKim, Ho-ShikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 9 407-412 (6 pages)
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced intrinsic apoptotic pathway. DZA activated typical caspase-dependent apoptosis in HL-60 cells, as demonstrated by an accumulation of hypo-diploidic cells, the processing of multiple procaspases and an inhibitory effect of z-VAD-Fmk on this cell death. During... -
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice
HyunJeongKim, Ji-InJung, YoungkyungKim, Jae-SeonLee, YoungWookYoon, JunesunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 7 157-161 (5 pages)
Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB)... -
Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?
JaeheeLee, SeungKeunBack, EunJeongLim, GyuChongCho, MyungAhKim, HeeJinKim, MinHeeLee, HeungSikNa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 1 59-69 (11 pages)
Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic pain could be induced or reversed by pharmacologically modulating spinal GABAergic activity, and whether quantitative alteration of spinal GABAergic elements after peripheral nerve injury was related to the impairment of GABAergic inhibition or neuropathic pain. To these aims,... -
Inhibition of β-amyloid1-40 Peptide Aggregation and Neurotoxicity by Citrate
YongHoonPark, Young-JinKim, IlHongSon, HyunDukYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 2 273-279 (7 pages)
The accumulation of Ղ-amyloid (AՂ) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit AՂ aggregate formation could be valuable therapeutics for AD. It is well known that aggregation of AՂ depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of AՂ, we considered using citrate, an anionic surfactant with three carboxylic acid groups. We... -
Mechanisms of Selective Antimicrobial Activity of Gaegurin 4
HeejeongKim, ByeongJaeLee, MunHanLee, SeongGeunHong, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 7 39-48 (10 pages)
(p＜0.05). Transmission electron microscopy revealed that GGN4 induced pore-like damages in M. luteus and dis-layering damages on the outer wall of E. coli. Taken together, the present results indicate that the selectivity of GGN4 toward Gram-positive over Gram-negative bacteria is due to negative surface charges, and interaction of GGN4 with outer walls. The selectivity toward bacteria over RBC is due to the presence of phosphatidylcholine and cholesterol, and the trans-bilayer lipid asymmetry... -
Alterations in Membrane Transport Function and Cell Viability Induced by ATP Depletion in Primary Cultured Rabbit Renal Proximal Tubular Cells
SungJuLee, ChaeHwaKwon, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 3 15-22 (8 pages)
This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide (KCN)/0.1 mM iodoacetic acid (IAA), and membrane transport function and cell viability were evaluated by measuring Na＋-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in Na＋-dependent phosphate...
