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Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking α-Calcitonin Gene-Related Peptide
JonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 4 299-304 (6 pages)
to the mice behaviors. αCGRP-knockout mice performed equally as well as wild type mice in the light-dark transition test and in the elevated plus maze test of anxiety. αCGRP-null mice behaved similarly as wild-type mice in the Porsolt swim test of depression. They also exhibited normal learning and memory in the fear conditioning tasks. It is concluded that αCGRP is not essential for mice to be able to perform these tests, despite the presence of αCGRP in the relevant regions of the brain. -
Interactions between Estradiol-17β-BSA and Calcitropic Hormones in Ca2+ Uptake in Renal Proximal Tubule Cells
HoJaeHan, YeunHeeLee, EunJuSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 5 261-268 (8 pages)
2 hours after E2-BSA (109 M) treatment, while estradiol-17β (109 M) did not affect. Treatment of the cells with E2-BSA (109 M) together with parathyroid hormone (PTH) (108 M), vitamin D (108 M), or calcitonin (108 M) significantly stimulated Ca2 uptake by 32.50%, 29.30%, or 27.75%, respectively, compared with the control. However, calcitropic hormones did not exhibit any synergistic effect on the E2-BSA-induced stimulation. E2-BSA significantly... -
Responses of Inferior Olive Neurons to Stimulation of Semicircular Canals
Sah-HoonPark, JongSeongPark, MinSuLee, JungWooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 4 193-198 (6 pages)
were very similar to otolithic or vertical-canal responses. Histologic identification of recording sites showed that most of vestibular IO neurons were located in β subnucleus. Electrical stimulation of a HSC evoked an inhibitory effect on the excitability of the ipsilateral IO neurons. These results suggest that IO neurons mainly in the β subnucleus receive vestibular signals from semicircular canals and otolithic organs, encode them, and transmit vestibular information to the cerebellum. -
Phytoestrogen-Induced Phosphorylation of MAP Kinase in Osteoblasts is Mediated by Membrane Estrogen Receptor
YounHeePark, HwanKiPark, HyoJinLee, SunMuPark, SangWonChoi, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 7 165-170 (6 pages)
analysis was performed in the presence and absence of the estrogen receptor antagonists, ICI 182,780 and tamoxifen. These antagonists blocked MAP kinase phosphorylation induced not only by E2, but also by the phytoestrogens. To the best our knowledge, this study is the first to demonstrate that phytoestrogens such as flavonoid and lignan extracted from safflower seeds produce a rapid activation of MAP kinase, at least partially via membrane estrogen receptor of the cultured osteoblastic cells. -
Molecular Mechanism of Pancreatic Bicarbonate Secretion
MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 1 131-138 (8 pages)
transporters needed for all forms of HCO3 secretion across the luminal membrane is the cystic fibrosis transmembrane conductance regulator (CFTR). In the resting state the pancreatic duct, and probably other HCO3 secretory epithelia, absorb HCO3. Interestingly, CFTR also control this mechanism. In this review, we discuss recent progress in understanding epithelial HCO3 transport, in particular the nature of the luminal transporters and their regulation by CFTR. -
Increases in Effective Cleft Glutamate Concentration During Expression of LTP
SuHyunJung, SukwooChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 8 113-120 (8 pages)
cleft since AMPA-type glutamate receptors are not generally saturated during basal transmission. Here we report evidence that peak cleft glutamate concentration ([glu]cleft) increases during LTP, as indicated by a lessening of the blocking effects of rapidly unbinding antagonists of AMPA. The efficacy of slowly equilibrating antagonists remained unchanged. The elevated [glu]cleft helps support the increased quantal amplitude of AMPA-type EPSCs (excitatory postsynaptic currents) during LTP. -
G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle
UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)
and generation of IP3 and IP3-dependent Ca2 release initiate the contraction. In smooth muscle cells derived from longitudinal muscle layer of the intestine, preferential hydrolysis of PC by PLA2, generation of AA and AA-mediated Ca2 influx, cADP ribose formation and Ca2-induced Ca2 release initiate the contraction. Sustained contraction, however, in both cell types is mediated by Ca2-independent mechanism involving activation of PKC-ε by DAG derived form PLD.... -
Pulse Exposure to Ethanol Augments Vascular Contractility Through Stress Response
Eun-KyoungYangInKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 7 47-53 (7 pages)
the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by 1μmol/L phorbol 12,13-dibutyrate, a protein kinase C activator, whether the tissues were exposed to 5% ethanol or not. This is the first report to show that even short exposure to ethanol has a delayed effect to increase vascular smooth muscle contractility through a modulation of thick filament regulation. It may be a mechanism by which ingestion of alcohol induces hypertension. -
Regulation of Immediate Early Gene Expression by Glutamate Receptor Activation in C6 Rat Glioma Cells
Jin-KooLee, Yung-HiKim, Seong-SooChoi, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 3 19-25 (7 pages)
CREB (cyclicAMP responsible element binding protein) proteins. The KA, NMDA, and glutamate did not affect forskolin- induced increase of ERK and CREB phosphorylation. The KA decreased PMA-induced increase of phosphorylation of ERK and CREB proteins, whereas glutamate and NMDA did not affect the phosphorylation of ERK and CREB proteins induced by PMA. These findings suggest that, in C6 glioma cells, c-fos mRNA induction induced by EAAs is not mediated by phosphorylation of ERK and CREB proteins. -
Differentiation of Neuroepithelial Progenitor Cells Implanted into Newborn Rat Brain Striatum
SungChoonKwon, JungSunPark, JeanJuLee, TaickSangNam, DongSooYeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 2 9-17 (9 pages)
investigate the differentiation of neuronal progenitor cells after transplantation into the neonatal rat forebrain striatum. Primary cultured progenitor cells were labeled with 3,3'-dioctadecycloxacarbonyl- amine perchlorate (DiO). DiO labeled progenitor cells were implanted into neonatal rat striatum. Implanted DiO labeled progenitor cells were differentiated into astrocytes and GABAergic neurons. These results suggest that implanted progenitor cells can be differentiated into neurons in host...


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