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Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity
JiaBak, HeeJungKim, SeongYunKim, Yun-SikChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 7 279-286 (8 pages)
HD was tested. For this purpose, male C57BL/6 mice were repeatedly given 3NP to induce HD-like pathogenesis, and 30 mg/ kg of CAPE or vehicle (5% dimethyl sulfoxide and 95% peanut oil) was administered daily. CAPE did not cause changes in body weight, but it reduced mortality by 29%. In addition, compared to the vehicle-treated group, robustly reduced striatal damage was observed in the CAPE-treated animals, and the 3NP-induced behavioral defi cits on the rotarod test were signifi cantly rescued... -
Involvement of Oxidative Stress and Poly(ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells
EunjooNam, YoungJaeLee, YoungAhOh, JinAhJung, HyeInIm, SeongEunKoh, SunghoMaeng, WanSeokJoo, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 6 325-331 (7 pages)
3-NP) inhibits electron transport in mitochondria, leading to a metabolic failure. In order to elucidate the mechanism underlying this toxicity, we examined a few biochemical changes possibly involved in the process, such as metabolic inhibition, generation of reactive oxygen species (ROS), DNA strand breakage, and activation of Poly(ADP-ribose) polymerase (PARP). Exposure of SK-N-BE(2)C neuroblastoma cells to 3-NP for 48 h caused actual cell death, while inhibition of mitochondrial function was... -
지연성 운동장애와 CAG 반복 확장
이상경, 박재훈, 박성우, 심주철, 이상수, 이정구, 안정미, 김도관, 김영훈 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 3호 3 399-408 (10 pages)
연구목적： 정신분열병환자에서 긴 CAG 반복서열의 빈도가 증가되어 있다는 보고가 있은 이후 이 불안정한 DNA가 정신분열병의 원인에 관여할 가능성에 대한 관심이 고조되어왔다. 항정신병약물에 의해 발생 되는 불수의적 운동장애의 하나인 지연성 운동장애(tardive dyskinesia；TD)는 CAG 반복 확장을 보이는 대표적인 운동장애의 하나인 헌팅톤씨 병과 많은 임상적, 생물학적 공통점을 갖고 있다. 저자 는 정신분열병 TD 환자에서 긴 CAG 반복 확장이 있는지를 조사하였다. 방 법： TD는 Abnormal Involuntary Movement Scale에...
