방출조절성 약제를 개발하기 위한 방법으로 polyacrylic acid와 polymethacrylic acid에 thionylchloride로 chlorination하여 cephalexine을 반응시켜 Polyacryloylcephalexine 과 polymethacryloylcephalexine을 합성하였다. Polyacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도로서 항균력은 Micrococcus luteus ATCC 9341과 Escherichia coli ESS이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925 균주들에 대해서도 항균성이 대체적으로 우수하였다. polymethacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도는 Micrococcus luteus ATCC 9341과 Klebsiella pueumouiae KCTC 1560이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925 균주들에 대해서는 항균력이 양호하였다.
Polyacryloylcephalexine and polymethacryloylcephalexine were prepared by the reaction of polyacryloylchloride or polymethacryloyl chloride with cephalexine. The antimicrobial activities of these polymeric drugs were investigated by the common twofold dilution technique and the minimum inhibitory concentration (MIC) of polymeric durgs was also examined. Polyacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Escherichia coli ESS, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925. Polymethacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Klebsiella pueumouiae KCTC 1560, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925.
