A nonstandard instrument used in the filed frequently becomes out-of-calibration due to environmental noise, misuse, aging, etc. A substantial amount of loss may result if such nonstandard instrument is used to check product quality and performance. Traditional periodic calibration at the calibration center is not capable of detecting out-of-calibration status while the instrument is in use, and therefore, statistical methods need to be developed to check the status of a nonstandard instrument in the field between calibrations. Developed in this paper is a unified measurement assurance model in which statistical calibration at the calibration center and measurement assurance test in the filed are combined. We developed statistical procedures to detect changes in precision and in the coefficients of the calibration equation. Futher, computational experiments are conducted to evaluate how the power of test varies with respect to the parameters involved. Based upon the computational results we suggest procedures for designing effective measurement assurance tests.