- 구내염증 치료용 구강점막 필름제의 제제설계와 약제학적 성질
- ㆍ 저자명
- 이계주,이덕근,신광현,박종범,Rhee. Gye-Ju,Lee. Duk-Keun,Sin. Kwang-Hyun,Park. Chong-Bum
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1999년|29권 2호|pp.127-136 (10 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form. The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using $Noveon^{circledR}$ AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, $Eudragit^{circledR}$ RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of $Noveon^{circledR}$ AA-1 or hydroxypropyl cellulose-M. The drug content was unifonnly $1160{pm}14.6;{mu}g$, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179 g of thickness, pH 5.7, 411 min of in vitro adhesion time and 172 g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.