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구내염증 치료용 구강점막 필름제의 제제설계와 약제학적 성질
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  • 구내염증 치료용 구강점막 필름제의 제제설계와 약제학적 성질
저자명
이계주,이덕근,신광현,박종범,Rhee. Gye-Ju,Lee. Duk-Keun,Sin. Kwang-Hyun,Park. Chong-Bum
간행물명
藥劑學會誌
권/호정보
1999년|29권 2호|pp.127-136 (10 pages)
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한국약제학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form. The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using $Noveon^{circledR}$ AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, $Eudragit^{circledR}$ RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of $Noveon^{circledR}$ AA-1 or hydroxypropyl cellulose-M. The drug content was unifonnly $1160{pm}14.6;{mu}g$, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179 g of thickness, pH 5.7, 411 min of in vitro adhesion time and 172 g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.