The objectives of this research are to establish the operation scheduling and the preventive maintenance system in order to optimize the operation of mailing center. For the optimal operation scheduling of mailing process, the existing workflow of mailing process and that of required time are investigated prior to simulation modeling. The simulation experiments are conducted to increase the nextday delivery rate. The best alternative whose nextday delivery rate up to 100% is selected based the AHP(Analytic Hierarchy Process) method. The optimal work scheduling of all mailing centers are also presented. In addition, the CMMS(Computerized Maintenance Management System) for preventive maintenance is introduced for efficient operation of highly automated facilities of mailing center.