This paper discusses the improved power performances of the size-reduced amplifier using defected ground structure (DGS). The slow-wave effect and enlarged electrical length occur due to the additional equivalent circuit elements of DGS. Using these properties, it is possible to reduce the length of transmission lines in order to keep the same original electrical lengths by inserting DGS on the ground plane. The matching and performances of the amplifier are preserved even after DGS patterns have been inserted. While there is no loss in the size-reduced transmission lines at the operating frequency, but there exists loss to some extent at harmonic frequencies. This leads to the more excellent inherent capability of harmonic rejection of the size-reduced amplifier. Therefore, it is expected tile harmonics of the size-reduced amplifier are smaller than those of the original amplifier. The measured second harmonic, third order intermodulation distortion (IMD3), and adjacent channel power ratio (ACPR) of the size-reduced amplifier are smaller than those of the original amplifier by 5 dB, 2~6 dB, and 1~4 dB, respectively, as expectation.