There is a rapidly growing expansion of internet-based infrastructure throughout industries in Korea. The internet-based Electronic Purchase and Supply System(EPSS) is being considered a supportive tool to increase the economic efficiency of hospital management. In this study, we conducted an economic evaluation of the system, analyzing data on four hospitals in Korea. According to the results, four hospitals was estimated to make net benefit of about 611 million Won in one year and about 2,809 million Won in the next five years. Further, the adoption of all hospitals in Korea to the system may generate net benefit of about 31,575 million Won in one year and about 166,938 million Won in the next five years. Furthermore, we expect that as the system covered many kinds of inputs in hospitals like pharmaceuticals, the benefit of the system would go up by a considerable degree.