Fatigue life of a Piston for large liquid Petroleum liquid injection(LPLi) bus engines is analyzed considering effects of cooling condition parameters : temperature of cooling water, and heat transfer coefficients at oil gallery and bottom surface of piston head. Temperature of the piston is analyzed with varying cooling conditions Stresses of the piston from two load cases of pressure loading. and pressure and thermal loading are analyzed Fatigue life under repeated peak pressure and thermal cycle is analyzed by the strain-life theory. For the two load cases, required loading cycles for engine life are defined, and loading cycles to failure and partial damages are calculated. Based on the resulting accumulated fatigue usage factors, endurance of the piston is evaluated and effects of varying cooling condition Parameters are discussed.