We study a family of 2-bridge knots with 2-tangles in the 3-sphere admitting a genus two 1-bridge splitting. We also observe a geometric relation between (g - 1, 1)-splitting and (g,0)- splitting for g = 2,3. Moreover we construct a family of closed orientable 3-manifolds which are n-fold cyclic coverings of the 3-sphere branched over those 2-bridge knots.