- 6-트리아졸 엑소메칠렌펜남 유도체의 합성
- Synthesis of 6-Triazole Exomethylenepenams Derivatives
- ㆍ 저자명
- 김연숙,오정석,임채욱,임철부
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 2004년|48권 5호|pp.303-308 (6 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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The synthesis of new 6-triazole exomethylenepenams was described. The 6,6-dibromopenam 5 was reacted with $CH_3$MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams 8 and 9, which were oxidized to sulfones 10 and 11 by m-CPBA. The p-methoxybenzyl compounds 6-11 were deprotected by AlCl$_3$ and neutralized to give the sodium salts 12-17.