The effects of inorganic salts and feather concentrations on pretense production by Bacillus megaterium F7-1 were investigated. Pretense production was dependent on the presence of phosphates in the medium. Supplementation of medium with calcium ion slightly increased protease production. The highest protease production was obtained at $1.4\%$ feather. The optimal medium contained $2.0\%$ glucose, $0.8\%$ skim milk, $0.06\%;K_{2}HPO_{4}\%,;0.04\%;KH_{2}PO{4},;0.06\%;NaCl,;0.03\%;MgCl_{2}cdot6H_{2}O,;0.002\%;CaCl_{2}cdot2H_{2}O,;and;1.4\%$ whole feather. By using this optimized medium, increased production of the protease was achieved compared with the cases of using basal medium.