For a long road tunnel, a tunnel ventilation system may be used in order to reduce the pollution level below the required level. To control the tunnel pollution level, a closed loop control algorithm may be used. The cascade control algorithm, which composed of a jet fan control algorithm and an air velocity setpoint algorithm, was developed to regulate the CO level in a tunnel. The verification of control algorithms was carried out by dynamic models developed from real tunnel data sets. The simulation results showed that control algorithms developed for this study were effective to control the tunnel ventilation system.