약물인 덱사메타손은 효과적인 염증치료제이다. 그러나 난용성 약물로써 수용액에서 주사제로 가용화가 어렵다. 따라서 º ¿±¸에서는 ¸Þ¸손을 수용액상에서 주사제로 가용화하기 §Ø¼ 지질로 만들어진 나노입자에 ¸Þ¸손을 봉입하여 체내투여 시 약물을 서서히 방출할 수 ´ 약물전달체를 제조하고자 ¿´´. 지질나노입자는 인지질, 콜레스테롤 ±×¸?簾? 양이온성 지질을 사용하여 자발 유화 ¿매확산법에 의해 제조하였다. ³ª노입자는 다양한 지질 종류와 지질의 함량에 따라서 봉입효율, 기 그리고 표면전하와 °°º ¹°리적 특성을 평가하였다. 기는 80~120 nm ¿´¸¸, 봉입효율은 80% 이상의 높은 효율을 보였다. 질의 지방쇄의 길이가 ±æ¼· 봉입효율은 증가하였고, 콜레스테롤의 량과 봉입효율은 반비례하였다. 나노지질입자는 양이온성 지질 없이는 형성되지 않았으며 ¾온성 지질의 ·?閻?¡ 따라서 봉입효율은 °¡하였다. 덱사메타손이 봉입된 지질나노입자는 난용성 약물을 주사제로 가용화 수 ´ 새로운 약물전달체로써의 가능성을 기대하는 바이다.
the coricosteroid drug dexamethasone is an efficacious antiinflammatory drug, it is difficult to formulate in an injectable formulation due to its poor aqueous solubility. A lipid-based nanosphere formulation containing dexamethasone was designed for solubilization of the drug in aqueous solution and sustained release of the drug from the nanosphere. The lipid nanospheres, composed of phospholipid, cholesterol and cationic lipid, were prepared by self emulsification-solvent diffusion method followed by diafiltration. Physicochemical characteristics such as mean particle diameter, zeta potential and drug loading efficiency of the lipid nanospheres were investigated according to the variation of either the kind of lipid or the lipid composition. The lipid nanospheres had a mean diameter 80-120 nm and dexamethasone loading efficiency of greater than 80%. The drug loading efficiency increased with the increase of the length of aliphatic chain attached to the phospholipid. However, the drug loading efficiency was inversely proportional to the increase of cholesterol content in the lipid composition. The lipid nanosphere could not be prepared without the use of cationic lipid and the drug loading efficiency was proportional to the increase of cationic lipid content. The lipid nanospheres containing dexamethasone are a promising novel drug carrier for an injectable formulation of the poorly water-soluble drugs.
