This study evaluate the effect of laundering on the deformation of knitted spandex/cotton fabrics compared with that of knitted cotton fabrics. Commercial knitted spandex/cotton and knitted cotton fabrics for T-shits were laundered in a drum-type washing machine and dried in a tumble dryer. Wale spirality, shrinkage, elastic recovery and surface contour of knitted fabrics were investigated under different laundering conditions: washing temperature, presoaking time and washing cycles. Knitted spandex/cotton fabrics had a lower angle of spirality than knitted cotton fabrics. After the first washing cycle, the angles of spirality of all the fabrics had decreased greatly. Knitted cotton fabric of low density deformed more than that of higher density. Knitted spandex/cotton. fabric of low density shrank less, because of the greater extension given during heat-set. Permanent elongation length at the 80$\%$ extension was longer than at the 50$\%$ extension, and the knitted spandex/cotton fabric which was expanded greatly during heat-set had a lower elastic recovery rate. The surface appearance of the knitted spandex/cotton fabrics was worsl~ than that of the knitted cotton fabrics before laundering and after repeated laundering, because of the much protruded cotton fibers from the yarns.