The objective of this study was to establish a systematic ergonomic program for the prevention and control of work-related musculoskeletal disorders(WMSDs) in a machinery manufacturing company. The steps such as looking for the signs of WMSDs problems, setting the stage for action, training-building in-house expertise, gathering and examining the evidence of WMSDS, developing controls of health care management, and proactive ergonomic interventions were applied. The primary success factors were management commitment and encouragement, and harmonious union-management relations.