The purpose of this study is to suggest the effective ventilation strategies and control methods that can minimize energy cost maintaining acceptable IAQ level in apartment house. The effects of the air-cleaning and heat-recovery ventilation system on IAQ under various operating conditions are investigated based on the experimental and CFD analyzed results. The results can be summarized as follows. (1) When a ventilator is not operated, the concentration of several pollutants may highly show in the house even though environment-friendly building materials are applied. Therefore, a mechanical ventilation system is required to obtain proper ventilation. (2) The pollutant concentration is noticeably deceased under air-cleaning/ventilation mode of air-clinic system, however, pollutant of kitchen is stagnant, because fresh air is not carried into the kitchen. (3) When air-clinic system is only equipped at master bedroom and living room, the system does not effectively deliver fresh air throughout the whole house, and then high pollutant concentration is obtained in each room. In contrast the average pollutant concentration meets the guideline when air-clinic system is installed at each room. (4) The air-cleaning/ventilation mode significantly affects on room ventilation in comparison with ventilation mode only.