Background: The purpose of this study was to investigate the effect of a Kinesio taping on muscle power and fatigue index in quadriceps femoris (vastus medialis, vastus lateralis, rectus femoris.). Methods: 15 male (heathy collegiate students) was enrolled from Kyungwoon university, Gumi. Kinesio tape was applied on quadriceps femoris muscle of subjects. Muscle power and fatigue index was measured by Wingate ergometer (warm-up was 30sec in 60W, maximum power test was 30sec in 100W, recovery was 30sec in 60W) in pre- and post applied taping. Results: As a results, there showed statistically significant improvement in mean power, peak power, mean power/kg, peak power/kg, fatigue index (p<.05). Conclusions: The study of Wingate test by applying Kinesio taping was significantly effected in mean power, peak power, mean power/kg, peak power/kg.