In the present paper, we focus on the flow computation of a low head Propeller turbine at a wide range of design and off-design operating conditions. First, we will present the results on the efficiency hill chart prediction of the Propeller turbine and discuss the consequences of using non-homologous blade geometries for the CFD simulation. The flow characteristics of the entire turbine will be also investigated and compared with experimental data at different measurement planes. Two operating conditions are selected, the first one at the best efficiency point and the second one at part load condition. At the same time, for the same selected operating points, the numerical results for the entire turbine simulation will be compared with flow simulation with our standard stage calculation approach which includes only guide vane, runner and draft tube geometries.