This study was performed to report the effectiveness of oriental medical treatment on a patient with Guillain-Barre syndrome complaining both lower extremity weakness. The patient was diagnosed as Guillain-Barre syndrome and treated with acupuncture, electroacupuncture, physical therapy and herbal medicine. We have evaluated the efficacy of oriental medical treatment by measuring changes of motor grade and ambulatory condition according to period of hospitalization. After treatment, motor grade and ambulatory condition were improved. These results suggest that oriental medical treatment was effective on the patient with Guillain-Barre syndrome.