This paper introduces design space exploration of many-core processors that meet high performance and low power required by the beamforming algorithm of image signals of mobile ultrasound. For the design space exploration of the many-core processor, we mapped different number of ultrasound image data to each processing element of many-core, and then determined an optimal many-core processor architecture in terms of execution time, energy efficiency and area efficiency. Experimental results indicate that PE=4096 and 1024 provide the highest energy efficiency and area efficiency, respectively. In addition, PE=4096 achieves 46x and 10x better than TI DSP C6416, which is widely used for ultrasound image devices, in terms of energy efficiency and area efficiency, respectively.