According to the advancement of computer and simulation method, it becomes possible to predict indoor climate precisely by using CFD simulation coupled with heat conduction, convection, and radiation. However, predicting the indoor climate is generally conducted by using a simplified CFD coupled simulation method since it takes quite long time to use a general CFD simulation method. In this study, a simplified CFD coupled simulation was conducted in order to find out the effect of natural ventilation by wind-driven in atrium. As a result of calculation, it was clarified that the natural ventilation driven by temperature difference was not enough to remove the accumulated heat of upper zone and the natural ventilation by wind-driven was needed. Finally, it is required to decide the window direction and size based on correct indoor climate prediction method for the effective use of natural ventilation by wind-driven.