The relevance between organisms and their external environment covers everything including humans, natural and artificial surroundings, regarding which academic and scientific understanding has continued. Relevant elements established by inter-dependence between humans and environment and the unity of life should be translated from the perspective of a whole, not of unit elements or reduction. That is, a space is formed by its own program and assumes sustainable relevance based on interactions between internal and external spaces, not building an independent system. The present study aims to present the feasibility of a potential mutant space formed by invisible arenas between individuals and evolutionary space formation based on an ecological paradigm Accordingly, this study suggested that evolutionary attributes as the major power source of biological changes could verify the virtual multiplicity of a new space formation, and that the potential form generation of hybrid mutant space of emergence and infinite formative capability could be supported. The suggestions made here will hopefully contribute to extending applicability of evolutionary space generation in the field of space design. To derive the potential mutant forms from biological space, a preliminary study was conducted regarding the characteristics of evolutionary form generation. For the purpose of this study, three evolutionary perspectives of reproduction, mutation (variation) and selection were taken. First, the theory of evolution was defined and characterized. Also, the relevance between the characteristics generated and hybrid mutant space was analyzed to consider relevant characteristics. The present study helped to understand that the hybrid mutant space had an evolutionary space structure based on a biological paradigm. It was also found that the mutant space structure built by mutant polymorphism assumed a systematic correlation between space and environment.