Purpose : This research the isotope of handling was to an actual act of the radiological defense which it follows in career of the clinical pathological companies in order to inquire the interrelation for a radiological defense. Materials and Methods : The tool of this research with question from 2010 October until November did electrification Chwung Cheng and the Seoul isotope thread clinical pathological company with the object person and it investigated in direct question or mail method, the data which is collected used SPSS19.0 programs and frequency and percentage and t-test, ANOVA, it used it analyzed a multiple regression analysis method. Results : The interrelationship of the radiological defense which it follows in career was visible the interrelation which considers statistically (p<0.01). But the correlation coefficient appeared lowly with 0.196. With the variable who affects in radiological defense act it appeared with worker providing by law educations and RI license acquisitions. Conclusion : There is to business progress and the radiological defense act respects a worker safety stands the unit only is the fact which is important. Consequently a possibility of saying that the radiation worker education is necessary, it executes the education which is continuous, RI license acquisitions, there is.